Professional Summary

  • My researches focus on delivery of macromolecules (oligonucleotides, proteins, genes) into brain and brain ischemia stroke.


  • M.D. : China Medical University
  • M.S. : China Medical University
  • PhD.: Texas Tech University

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Positions and Work Experience
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  • Assistant Professor ,University of Cincinnati,Cincinnati OH
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Research Grants
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  • 12BGIA909000001/01/2012-12/31/2013. American Heart Association - Great Rivers Affiliate. Therapy of Stroke with Novel Neuroprotective RNA Nanoparticles, PI, Active.
  • RRIA 201205/08/2012-09/30/2013. Michael J. Fox Foundation for Parkinson's Research. The Mifunctional Cembranoids for Therapy of Parkinson's Disease, PI, Active.
  • 2013-PH-012SR07/01/2013-06/30/2014. Maine Cancer Foundation. Inhibition of Intercellular Adhesion Molecule-1 in Lung Cancer Cells by Selective SiRNA Nanoparticles, PI, Awarded.
  • R15NS08838404/01/2015-03/31/2018. National Institute of Neurological Disorders and Stroke. Targeting the Blood-Brain Barrier in Ischemic Stroke, PI, Awarded.
  • R21NS093493-0106/01/2015-05/31/2017. National Institute of Neurological Disorders and Stroke. Application of Brain-Targeted Anti-inflammatory RNA Nanoparticle for Ischemic Stroke Therapy, PI, Awarded.
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Peer Reviewed Publications (in chronological order)
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  • Hu, J., Xiao, F., Hao, X., Bai, S., & Hao, J. (2014). Inhibition of monocyte adhesion to brain-derived endothelial cells by dual functional RNA chimeras.. Molecular Therapy. Nucleic Acids, 3, e209. doi:10.1038/mtna.2014.60
  • Hu, J., Mu, C., & Hao, J. (2013). Cerebral ischemia reduces expression of Hs1-associated protein X-1 (Hax-1) in mouse brain.. Neuroscience Letters, 534, 338-43. doi:10.1016/j.neulet.2012.12.009
  • Mu, C., Dave, N., Hu, J., Desai, P., Pauletti, G., Bai, S., & Hao, J. (2013). Solubilization of flurbiprofen into aptamer-modified PEG-PLA micelles for targeted delivery to brain-derived endothelial cells in vitro.. Journal of Microencapsulation, 30 (7), 701-8. doi:10.3109/02652048.2013.778907
  • Hao, J., & Bickel, U. (2013). Transferrin receptor mediated brain uptake during ischemia and reperfusion.. Journal of Pharmacy & Pharmaceutical Sciences : A Publication of the Canadian Society For Pharmaceutical Sciences, Soci & #233;t & #233; Canadienne Des Sciences Pharmaceutiques, 16 (4), 541-50.
  • Yang, T., Nyiawung, D., Silber, A., Hao, J., Lai, L., & Bai, S. (2012). Comparative studies on chitosan and polylactic-co-glycolic acid incorporated nanoparticles of low molecular weight heparin.. AAPS PharmSciTech, 13 (4), 1309-18. doi:10.1208/s12249-012-9854-8
  • Hao, J., Mdzinarishvili, A., Abbruscato, T. J., Klein, J., Geldenhuys, W. J., Van der Schyf, C. J., & Bickel, U. (2008). Neuroprotection in mice by NGP1-01 after transient focal brain ischemia.. Brain Research, 1196, 113-20. doi:10.1016/j.brainres.2007.11.075
  • Ferchmin, P. A., Hao, J., Perez, D., Penzo, M., Maldonado, H. M., Gonzalez, M. T., Rodriguez, A. D., & de Vellis, J. (2005). Tobacco cembranoids protect the function of acute hippocampal slices against NMDA by a mechanism mediated by alpha4beta2 nicotinic receptors.. Journal of Neuroscience Research, 82 (5), 631-41. doi:10.1002/jnr.20666
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Animal Protocols
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  • Principal Investigator
    Therapy for ischemic and inflammatory diseases model13-03-05-01
    Approved     Exp. Date: 04/04/2019
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