Professional Summary

  • Brain tumors are now the leading cause of cancer related deaths in children. The Phoenix lab is focused on advancing our understanding of brain tumor diversity, and developing new tools and therapies to improve patient outcome. Current projects build on our expertise in developmental neurobiology, genomics, and tumor microenvironment interactions. These include 1) Defining mechanisms of primary brain tumor metastasis; 2) Developing novel animal models of pediatric brain tumors for preclinical studies; 3) Determining vascular heterogeneity and barriers in pediatric brain tumors. 

Education

  • BS: Syracuse University, 2002
  • PhD: Albany Medical College, 2010

[Collapse All]

[Expand All]


Post Graduate Training/Education
Back to Top
  • Postdoctoral Fellow.
    2010-2016, St. Jude Children's Research Hospital., Memphis, TN, My postdoctoral work focused on understanding how genetic alterations dictate differences in brain tumor subgroup biology and treatment response.
Back to Top
Positions and Work Experience
Back to Top
  • 2016,Assistant Professor.,Division of Pharmaceutical Sciences.,University of Cincinnati, College of Pharmacy.,Cincinnati, OH
  • 2002-2004,Technical Research Associate.,University of Rochester.,Rochester, NY
Back to Top
Research Grants
Back to Top
  • N/A.12/01/2016-11/30/2017. UC Brain Tumor Center.. Determining Mechanisms of Metastasis in Medulloblastoma Subgroups. - Grant, PI, Active.
  • N/A.01/01/2017-12/31/2017. UC Gardner Neuroscience Institute.. Developing Novel Preclinical Models of Pediatric Brain Tumors. - Grant, Co-PI and Mentor, Active.
Back to Top
Peer Reviewed Publications (in chronological order)
Back to Top
  • Phoenix TN, Patmore DM, Boop, S, Boulos N, Jacus MO, Patel YT, Roussel MF, Goumnerova L, Perreault S, Wadhwa E, Cho YJ, Roussel MF, Stewart CF, Gilbertson, RJ. (2016). Medulloblastoma genotype dictates blood brain barrier phenotype. Cancer Cell, 29 (4), 508-22. [PubMed Link]
  • Eden CJ, Ju B, Murugesan M, Phoenix TN, Nimmervoll B, Tong Y, Ellison DW, Finkelstein D, Wright K, Boulos N, Dapper J, Thiruvenkatam R, Lessman CA, Taylor MR, Gilbertson RJ. (2014). Orthotopic models of pediatric brain tumors in zebrafish.. Oncogene, 34 (13), 1736-42. [PubMed Link]
  • Parker M, Mohankumar KM, Punchihewa C, Weinlich R, Dalton JD, Li Y, Lee R, Tatevossian RG, Phoenix TN, Thiruvenkatam R, White E, Tang B, Orisme W, Gupta K, Rusch M, Chen X, Li Y, Nagahawhatte P, Hedlund E, Finkelstein D, Wu G, Shurtleff S, Easton J, Boggs K, Yergeau D, Vadodaria B, Mulder HL, Becksfort J, Gupta P, Huether R, Ma J, Song G, Gajjar A, Merchant T, Boop F, Smith AA, Ding L, Lu C, Ochoa K, Zhao D, Fulton RS, Fulton LL, Mardis ER, Wilson RK, Downing JR, Green DR, Zhang J, Ellison DW, Gilbertson RJ. (2014). C11orf95-RELA fusions drive oncogenic NF-kB signalling in ependymoma. Nature, 506 (7489), 451-55. [PubMed Link]
  • Robinson G, Parker M, Kranenberg TA, Lu C, Chen X, Ding L, Phoenix TN, Hedlund E, Lei W, Zhu X, Chalhoub N, Baker SJ, Huether R, Wang J, Wu G, Rusch M, Hong X, Becksford J, Gupta P, Ma J, Easton J, Pounds S, Zhao D, Gajjar A, Kawauchi D, Roussel MF, Finkelstein D, Ellison DW, Fulton LL, Dooling DJ, Ochoa K, Mardis ER, Wilson RK, Downing JR, Zhang J, Gilbertson RJ. (2012). Novel Mutations Target Distinct Subgroups of Medulloblastoma. Nature, 488 (7409), 43-48. [PubMed Link]
  • Liddelow SA, Temple S, Møllgård K, Gehwolf R, Wagner A, Bauer H, Bauer HC, Phoenix TN, Dziegielewska KM, Saunders NR. (2012). Molecular Characterization of Transport Mechanisms at the Developing Mouse Blood-CSF Interface: a Transcriptome Approach. PLoS One, 7 (3), e33554. [PubMed Link]
  • Atkinson JM, Shelat AA, Carcaboso AM, Kranenburg TA, Arnold LA, Boulos N, Wright K, Johnson RA, Poppleton H, Mohankumar KM, Féau C, Phoenix T, Gibson P, Zhu L, Tong Y, Eden C, Ellison DW, Priebe W, Koul D, Yung WK, Gajjar A, Stewart CF, Guy RK, Gilbertson RJ. (2011). An Integrated In Vitro and In Vivo High-Throughput Screen Identifies Treatment Leads for Ependymoma. Cancer Cell, 20 (3), 384-99. [PubMed Link]
  • Liddelow SA, Dziegielewska KM, Møllgård K, Phoenix TN, Temple S, Vandeberg JL, Saunders NR. (2011). SPARC/Osteonectin, an Endogenous Mechanism for Targeting Albumin to the Blood-Cerebrospinal Fluid Interface During Brain Development. European Journal of Neuroscience, 34 (7), 1062-73. [PubMed Link]
  • Phoenix TN, and Temple S. (2010). Spred1, a Negative Regulator of MAPK-ERK, is Enriched in CNS Germinal Zones, Dampens NSC Proliferation and Maintains Neuroepithelial Structure. Genes and Development, 24 (1), 45-56. [PubMed Link]
  • Fasano CA, Phoenix TN, Kokovay E, Lowry N, Elkabetz Y, Dimos J, Lemischka I, Studer L, Temple S. (2009). BMI-1 Regionally Maintains Neurogenic Stem Cells in the Forebrain. Genes and Development, 23 (5), 561-74. [PubMed Link]
  • Shen Q, Wang Y, Dimos JT, Fasano CA, Phoenix TN, Lemischka IR, Ivanova NB, Stifani S, Morrisey EE, and Temple S. (2006). The Timing of Cortical Neurogenesis is Encoded Within Lineages of Individual Progenitor Cells. Nature Neuroscience, 9 (6), 743-51. [PubMed Link]
Back to Top
Invited Publications
Back to Top
  • Phoenix TN. and Gilbertson RJ. (2012). There’s a time and a place for N-Myc.. Cancer Cell., 21 (5), 593-95. [PubMed Link]
  • Phoenix TN, Currle S, Robinson G, Gilbertson RJ. (2012). Developmental Origins of Neural Tumors: Old Ideas, New Approaches.. Neuropathology and Applied Neurobiology., 38 (3), 222-27. [PubMed Link]
  • Phoenix, TN, and Temple S. (2009). Baby Got Brain: Fgf10 Sets Rostral Cortical Size.. Neuron., 63 (1), 1-3. [PubMed Link]
Back to Top
Invited Presentations
Back to Top
  • Timothy Phoenix, Deanna Patmore, Scott Boop, Megan Jacus, Yogesh Patel, Liliana Goumnerova, Sebastien Perreault, Elizabeth Wadhwa, Yoon-Jae Cho, Clinton Stewart, and Richard Gilbertson. (2015). Medulloblastoma subtypes specify inter-tumoral vascular blood brain barrier heterogeneity..Pediatric Neuro-Oncology Basic and Translational Research Conference ,San Diego, CA.
  • Timothy Phoenix, Deanna Patmore, Scott Boop, Megan Jacus, Yogesh Patel, Liliana Goumnerova, Sebastien Perreault, Elizabeth Wadhwa, Yoon-Jae Cho, Clinton Stewart, and Richard Gilbertson. (2014). Medulloblastoma subtypes specify inter-tumoral vascular blood brain barrier heterogeneity.International Society for Pediatric Neuro-oncology ,Singapore.
Back to Top
Poster Presentations
Back to Top
  • Timothy Phoenix, Deanna Patmore, Scott Boop, Megan Jacus, Yogesh Patel, Liliana Goumnerova, Sebastien Perreault, Elizabeth Wadhwa, Yoon-Jae Cho, Clinton Stewart, and Richard Gilbertson. (2016). Medulloblastoma genotype dictates blood brain barrier phenotype.Sohn Conference: Pediatric Cancer in a Post-Genomic World ,New York, NY.
  • Timothy N. Phoenix and Sally Temple (2009). Spred1, a negative regulator of MAPK-ERK, is enriched in CNS germinal zones, dampens NSC proliferation and maintains neuroepithelial structure.International Society for Stem Cell Research Meeting ,Barcelona, Spain.
  • Timothy N. Phoenix and Sally Temple. (2009). Spred1, a negative regulator of MAPK-ERK, is enriched in CNS germinal zones, dampens NSC proliferation and maintains neuroepithelial structure.NIH Graduate Student Research Festival ,Bethesda, MD.
Back to Top
Animal Protocols
Back to Top
  • Principal Investigator
    Identifying Regulators of Brain Tumor Pathogenesis16-07-06-01
    Approved     Exp. Date: 08/29/2019
Back to Top