Education

  • Undergraduate: University of Notre Dame, 1995
  • Doctoral Degree: University of Pittsburgh School of Medicine, 2000

Research/Clinical Interests

  • Areas of expertise - pathophysiology and treatment of traumatic brain injury and stroke, with emphasis on spreading depression, seizures, and neuromonitoring

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Positions and Work Experience
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  • 2008-to Present,Director of Clinical Monitoring,Mayfield Clinic,Cincinnati, Ohio
  • 2008-to Present,Research Assistant Professor, Department of Neurosurgery,University of Cincinnati College of Medicine,Cincinnati, Ohio
  • 2004-2008,Chief, Neurophysiology Laboratory, Division of Psychiatry and Neuroscienceoscience, 2004-2008,Walter Reed Army Institute of Research,Silver Spring, Maryland
  • 2006-2008,U.S. Army: Major,Medical Service Corps
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Research Grants
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  • W81XWH-08-2-001609/01/2008-08/30/2012. Department of the Army Medical Research and Materiel Command. Spreading Depressions as Secondary Insults after Traumatic Injury to the Human Brain, PI, Active.
  • IPA DOD11/01/2008-08/31/2012. Department of the Army Medical Research and Materiel Command. Intergovernmental Personnel Act Agreement for Jed Hartings, PI, Active.
  • W81XWH-10-1-0977 / W91ZSQ0128N61009/30/2010-10/29/2015. Department of the Army Medical Research Acquisition Activity. Novel Smart Catheter for Multimodal Monitoring of the Head-Injured Warrior, PI, Active.
  • Hartings 201202/08/2012-02/07/2013. Upsher-Smith Laboratories, Inc.. Consulting Agreement with Upsher-Smith Laboratories, Inc, PI, Active.
  • Agreement No. 602150-209/01/2013-08/31/2014. European Union Commission. Collaboratirve European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI), PI, Active.
  • HOPES05/01/2015-04/30/2018. Vivian L Smith Foundation for Neurological Research. HypOthermia for Patients requiring Evacuation of Subdural Hematoma (HOPES): a Multicenter, Randomized Clinical Trial, Collaborator, Active.
  • W81XWH-16-2-0020 / BA15007507/15/2016-07/14/2020. Department of the Army Medical Research Acquisition Activity. Development and Validation of Spreading Depolarization Monitoring for TBI Management, PI, Awarded.
  • 2016-17 R. J. Dempsey Cerebrovascular Research Award07/01/2016-06/30/2017. American Association of Neurological Surgeons. Non-Traumatic Sulcal Subarachnoid Hemorrhage in a Porcine Model: Induction of Cortical Spreading Depolarization and Early Cortical Ischemia, PI, Active.
  • W81XWH-16-C-016109/30/2016-12/29/2020. Department of the Army Medical Research Acquisition Activity. Hypothermia for Patients Requiring Evacuation of Subdural Hematoma: Effect on Spreading Depolarizations, PI, Awarded.
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Peer Reviewed Publications (in chronological order)
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  • Hartings, J. A., & Dreier, J. P. (2017). Real-time detection of lesion development in acute brain injury.. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 37 (5), 1550-1552. doi:10.1177/0271678X16677764
  • Pinczolits, A., Zdunczyk, A., Dengler, N. F., Hecht, N., Kowoll, C. M., Dohmen, C., Graf, R., Winkler, M. K., Major, S., Hartings, J. A., Dreier, J. P., Vajkoczy, P., & Woitzik, J. (2017). Standard-sampling microdialysis and spreading depolarizations in patients with malignant hemispheric stroke.. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 37 (5), 1896-1905. doi:10.1177/0271678X17699629
  • Hartings, Jed A (2017). Spreading depolarization monitoring in neurocritical care of acute brain injury.. Current Opinion in Critical Care, 23 (2), 94-102. doi:10.1097/MCC.0000000000000395
  • Li, C., Wu, Z., Limnuson, K., Cheyuo, C., Wang, P., Ahn, C. H., Narayan, R. K., & Hartings, J. A. (2016). Development and application of a microfabricated multimodal neural catheter for neuroscience.. Biomedical Microdevices, 18 (1), 8. doi:10.1007/s10544-016-0034-6
  • Li, C., Narayan, R. K., Wu, P., Rajan, N., Wu, Z., Mehan, N., Golanov, E. V., Ahn, C. H., & Hartings, J. A. (2016). Evaluation of microelectrode materials for direct-current electrocorticography.. Journal of Neural Engineering, 13 (1), 016008. doi:10.1088/1741-2560/13/1/016008
  • Toth, P., Szarka, N., Farkas, E., Ezer, E., Czeiter, E., Amrein, K., Ungvari, Z., Hartings, J. A., Buki, A., & Koller, A. (2016). Traumatic brain injury-induced autoregulatory dysfunction and spreading depression-related neurovascular uncoupling: Pathomechanisms, perspectives, and therapeutic implications.. American Journal of Physiology. Heart and Circulatory Physiology, 311 (5), H1118-H1131. doi:10.1152/ajpheart.00267.2016
  • Li, C., Narayan, R. K., Wang, P., & Hartings, J. A. (2016). Regional temperature and quantitative cerebral blood flow responses to cortical spreading depolarization in the rat.. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. doi:10.1177/0271678X16667131
  • Hartings, J. A., Shuttleworth, C. W., Kirov, S. A., Ayata, C., Hinzman, J. M., Foreman, B., Andrew, R. D., Boutelle, M. G., Brennan, K. C., Carlson, A. P., Dahlem, M. A., Drenckhahn, C., Dohmen, C., Fabricius, M., Farkas, E., Feuerstein, D., Graf, R., Helbok, R., Lauritzen, M., Major, S., Oliveira-Ferreira, A. I., Richter, F., Rosenthal, E. S., Sakowitz, O. W., Sánchez-Porras, R., Santos, E., Schöll, M., Strong, A. J., Urbach, A., Westover, M. B., Winkler, M. K., Witte, O. W., Woitzik, J., & Dreier, J. P. (2016). The continuum of spreading depolarizations in acute cortical lesion development: Examining Leão's legacy.. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. doi:10.1177/0271678X16654495
  • Dreier, J. P., Fabricius, M., Ayata, C., Sakowitz, O. W., William Shuttleworth, C., Dohmen, C., Graf, R., Vajkoczy, P., Helbok, R., Suzuki, M., Schiefecker, A. J., Major, S., Winkler, M. K., Kang, E., Milakara, D., Oliveira-Ferreira, A. I., Reiffurth, C., Revankar, G. S., Sugimoto, K., Dengler, N. F., Hecht, N., Foreman, B., Feyen, B., Kondziella, D., Friberg, C. K., Piilgaard, H., Rosenthal, E. S., Westover, M. B., Maslarova, A., Santos, E., Hertle, D., Sánchez-Porras, R., Jewell, S. L., Balança, B., Platz, J., Hinzman, J. M., Lückl, J., Schoknecht, K., Schöll, M., Drenckhahn, C., Feuerstein, D., Eriksen, N., Horst, V., Bretz, J. S., Jahnke, P., Scheel, M., Bohner, G., Rostrup, E., Pakkenberg, B., Heinemann, U., Claassen, J., Carlson, A. P., Kowoll, C. M., Lublinsky, S., Chassidim, Y., Shelef, I., Friedman, A., Brinker, G., Reiner, M., Kirov, S. A., Andrew, R. D., Farkas, E., Güresir, E., Vatter, H., Chung, L. S., Brennan, K. C., Lieutaud, T., Marinesco, S., Maas, A. I., Sahuquillo, J., Dahlem, M. A., Richter, F., Herreras, O., Boutelle, M. G., Okonkwo, D. O., Bullock, M. R., Witte, O. W., Martus, P., van den Maagdenberg, A. M., Ferrari, M. D., Dijkhuizen, R. M., Shutter, L. A., Andaluz, N., Schulte, A. P., MacVicar, B., Watanabe, T., Woitzik, J., Lauritzen, M., Strong, A. J., & Hartings, J. A. (2016). Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group.. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. doi:10.1177/0271678X16654496
  • Hartings, J. A., Li, C., Hinzman, J. M., Shuttleworth, C. W., Ernst, G. L., Dreier, J. P., Wilson, J. A., Andaluz, N., Foreman, B., & Carlson, A. P. (2016). Direct current electrocorticography for clinical neuromonitoring of spreading depolarizations.. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. doi:10.1177/0271678X16653135
  • Drenckhahn, C., Windler, C., Major, S., Kang, E., Scheel, M., Vajkoczy, P., Hartings, J. A., Woitzik, J., & Dreier, J. P. (2016). Complications in Aneurysmal Subarachnoid Hemorrhage Patients With and Without Subdural Electrode Strip for Electrocorticography.. Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society, 33 (3), 250-9. doi:10.1097/WNP.0000000000000274
  • Bogdanov, V. B., Middleton, N. A., Theriot, J. J., Parker, P. D., Abdullah, O. M., Ju, Y. S., Hartings, J. A., & Brennan, K. C. (2016). Susceptibility of Primary Sensory Cortex to Spreading Depolarizations.. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience, 36 (17), 4733-43. doi:10.1523/JNEUROSCI.3694-15.2016
  • Winkler, M. K., Dengler, N., Hecht, N., Hartings, J. A., Kang, E. J., Major, S., Martus, P., Vajkoczy, P., Woitzik, J., & Dreier, J. P. (2016). Oxygen availability and spreading depolarizations provide complementary prognostic information in neuromonitoring of aneurysmal subarachnoid hemorrhage patients.. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. doi:10.1177/0271678X16641424
  • Maas, A. I. R., Menon, D. K., Steyerberg, E. W., Citerio, G., Lecky, F., Manley, G. T., Hill, S., Legrand, V., & Sorgner, A. (2015). Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI): a prospective longitudinal observational study.. Neurosurgery, 76 (1), 67-80. doi:10.1227/NEU.0000000000000575
  • Tackla, R., Hinzman, J. M., Foreman, B., Magner, M., Andaluz, N., & Hartings, J. A. (2015). Assessment of Cerebrovascular Autoregulation Using Regional Cerebral Blood Flow in Surgically Managed Brain Trauma Patients.. Neurocritical Care. doi:10.1007/s12028-015-0146-5
  • Hinzman, J. M., DiNapoli, V. A., Mahoney, E. J., Gerhardt, G. A., & Hartings, J. A. (2015). Spreading depolarizations mediate excitotoxicity in the development of acute cortical lesions.. Experimental Neurology, 267, 243-53. doi:10.1016/j.expneurol.2015.03.014
  • Hinzman, J. M., Gibson, J. L., Tackla, R. D., Costello, M. S., Burmeister, J. J., Quintero, J. E., Gerhardt, G. A., & Hartings, J. A. (2015). Real-time monitoring of extracellular adenosine using enzyme-linked microelectrode arrays.. Biosensors & Bioelectronics, 74, 512-517. doi:10.1016/j.bios.2015.06.074
  • Li, C., Wu, P., Wu, Z., Limnuson, K., Mehan, N., Mozayan, C., Golanov, E. V., Ahn, C. H., Hartings, J. A., & Narayan, R. K. (2015). Highly accurate thermal flow microsensor for continuous and quantitative measurement of cerebral blood flow.. Biomedical Microdevices, 17 (5), 9992. doi:10.1007/s10544-015-9992-3
  • Li, C., Limnuson, K., Wu, Z., Amin, A., Narayan, A., Golanov, E. V., Ahn, C. H., Hartings, J. A., & Narayan, R. K. (2015). Single probe for real-time simultaneous monitoring of neurochemistry and direct-current electrocorticography.. Biosensors & Bioelectronics, 77, 62-68. doi:10.1016/j.bios.2015.09.021
  • Hinzman, J., Wilson, J. A., Mazzeo, A. T., Bullock, R., & Hartings, J. A. (2015). Excitotoxicity and Metabolic Crisis Are Associated with Spreading Depolarizations in Severe Traumatic Brain Injury Patients.. Journal of Neurotrauma. doi:10.1089/neu.2015.4226
  • Jeffcote, T., Hinzman, J. M., Jewell, S. L., Learney, R. M., Pahl, C., Tolias, C., Walsh, D. C., Hocker, S., Zakrzewska, A., Fabricius, M. E., Strong, A. J., Hartings, J. A., & Boutelle, M. G. (2014). Detection of spreading depolarization with intraparenchymal electrodes in the injured human brain.. Neurocritical Care, 20 (1), 21-31. doi:10.1007/s12028-013-9938-7
  • Hartings, J. A., Wilson, J. A., Look, A. C., Vagal, A., Shutter, L. A., Dreier, J. P., Ringer, A., & Zuccarello, M. (2013). Full-band electrocorticography of spreading depolarizations in patients with aneurysmal subarachnoid hemorrhage.. Acta Neurochirurgica. Supplement, 115, 131-41. doi:10.1007/978-3-7091-1192-5_27
  • Dreier, J. P., Drenckhahn, C., Woitzik, J., Major, S., Offenhauser, N., Weber-Carstens, S., Wolf, S., Strong, A. J., Vajkoczy, P., & Hartings, J. A. (2013). Spreading Ischemia After Aneurysmal Subarachnoid Hemorrhage.. Acta Neurochirurgica. Supplement, 115, 125-129. doi:10.1007/978-3-7091-1192-5_26
  • Wilson, J. A., Shutter, L. A., & Hartings, J. A. (2013). COSBID-M3: A Platform for Multimodal Monitoring, Data Collection, and Research in Neurocritical Care.. Acta Neurochirurgica. Supplement, 115, 67-74. doi:10.1007/978-3-7091-1192-5_15
  • Hartings, J. A., Vidgeon, S., Strong, A. J., Zacko, C., Vagal, A., Andaluz, N., Ridder, T., Stanger, R., Fabricius, M., Mathern, B., Pahl, C., Tolias, C. M., & Bullock, M. R. (2013). Surgical management of traumatic brain injury: a comparative-effectiveness study of 2 centers.. Journal of Neurosurgery. doi:10.3171/2013.9.JNS13581
  • Serrone, J. C., Wash, E. M., Hartings, J. A., Andaluz, N., & Zuccarello, M. (2013). Venous Thromboembolism in Subarachnoid Hemorrhage.. World Neurosurgery. doi:10.1016/j.wneu.2013.01.012
  • Li, C., Wu, P., Hartings, J. A., Wu, Z., Cheyuo, C., Wang, P., Ledoux, D., Shutter, L. A., Ramaswamy, B. R., Ahn, C. H., & Narayan, R. K. (2012). Micromachined lab-on-a-tube sensors for simultaneous brain temperature and cerebral blood flow measurements.. Biomedical Microdevices. doi:10.1007/s10544-012-9646-7
  • Drenckhahn, C., Winkler, M. K. L., Major, S., Scheel, M., Kang, E., Pinczolits, A., Grozea, C., Hartings, J. A., Woitzik, J., & Dreier, J. P. (2012). Correlates of spreading depolarization in human scalp electroencephalography.. Brain : A Journal of Neurology, 135 (Pt 3), 853-68. doi:10.1093/brain/aws010
  • Li, C., Wu, P., Wu, Z., Ahn, C. H., LeDoux, D., Shutter, L. A., Hartings, J. A., & Narayan, R. K. (2012). Brain temperature measurement: A study of in vitro accuracy and stability of smart catheter temperature sensors.. Biomedical Microdevices, 14 (1), 109-18. doi:10.1007/s10544-011-9589-4
  • Dreier, J. P., Major, S., Pannek, H., Woitzik, J., Scheel, M., Wiesenthal, D., Martus, P., Winkler, M. K. L., Hartings, J. A., Fabricius, M., Speckmann, E., & Gorji, A. (2012). Spreading convulsions, spreading depolarization and epileptogenesis in human cerebral cortex.. Brain : A Journal of Neurology, 135 (Pt 1), 259-75. doi:10.1093/brain/awr303
  • Hertle, D. N., Dreier, J. P., Woitzik, J., Hartings, J. A., Bullock, R., Okonkwo, D. O., Shutter, L. A., Vidgeon, S., Strong, A. J., Kowoll, C., Dohmen, C., Diedler, J., Veltkamp, R., Bruckner, T., Unterberg, A. W., & Sakowitz, O. W. (2012). Effect of analgesics and sedatives on the occurrence of spreading depolarizations accompanying acute brain injury.. Brain : A Journal of Neurology, 135 (Pt 8), 2390-2398. doi:10.1093/brain/aws152
  • Li, C., Wu, Z., Hartings, J. A., Rajan, N., Chahine, N., Cheyuo, C., Wang, P., Wu, P., Golanov, E. V., Ahn, C. H., & Narayan, R. K. (2012). Brain-friendly amperometric enzyme biosensor based on encapsulated oxygen generating biomaterial.. Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 2012, 6003-6. doi:10.1109/EMBC.2012.6347362
  • Hartings, J. A., Bullock, M. R., Okonkwo, D. O., Murray, L. S., Murray, G. D., Fabricius, M., Maas, A. I., Woitzik, J., Sakowitz, O., Mathern, B., Roozenbeek, B., Lingsma, H., Dreier, J. P., Puccio, A. M., Shutter, L. A., Pahl, C., & Strong, A. J. (2011). Spreading depolarisations and outcome after traumatic brain injury: a prospective observational study.. Lancet Neurology, 10 (12), 1058-64. doi:10.1016/S1474-4422(11)70243-5
  • Fioravanti, B., Kasasbeh, A., Edelmayer, R., Skinner, D. P., Hartings, J. A., Burklund, R. D., De Felice, M., French, E. D., Dussor, G. O., Dodick, D. W., Porreca, F., & Vanderah, T. W. (2011). Evaluation of cutaneous allodynia following induction of cortical spreading depression in freely moving rats.. Cephalalgia : An International Journal of Headache, 31 (10), 1090-100. doi:10.1177/0333102411410609
  • Hartings, J. A., Watanabe, T., Bullock, M. R., Okonkwo, D. O., Fabricius, M., Woitzik, J., Dreier, J. P., Puccio, A., Shutter, L. A., Pahl, C., & Strong, A. J. (2011). Spreading depolarizations have prolonged direct current shifts and are associated with poor outcome in brain trauma.. Brain : A Journal of Neurology, 134 (Pt 5), 1529-40. doi:10.1093/brain/awr048
  • Lauritzen, M., Dreier, J. P., Fabricius, M., Hartings, J. A., Graf, R., & Strong, A. J. (2011). Clinical relevance of cortical spreading depression in neurological disorders: migraine, malignant stroke, subarachnoid and intracranial hemorrhage, and traumatic brain injury.. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 31 (1), 17-35. doi:10.1038/jcbfm.2010.191
  • Lu, X. M., Hartings, J. A., Si, Y., Balbir, A., Cao, Y., & Tortella, F. C. (2011). Electrocortical pathology in a rat model of penetrating ballistic-like brain injury.. Journal of Neurotrauma, 28 (1), 71-83. doi:10.1089/neu.2010.1471
  • Oliveira-Ferreira, A. I., Milakara, D., Alam, M., Jorks, D., Major, S., Hartings, J. A., Lückl, J., Martus, P., Graf, R., Dohmen, C., Bohner, G., Woitzik, J., & Dreier, J. P. (2010). Experimental and preliminary clinical evidence of an ischemic zone with prolonged negative DC shifts surrounded by a normally perfused tissue belt with persistent electrocorticographic depression.. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 30 (8), 1504-19. doi:10.1038/jcbfm.2010.40
  • Eriksen, N., Rostrup, E., Andersen, K., Lauritzen, M. J., Fabricius, M., Larsen, V. A., Dreier, J. P., Strong, A. J., Hartings, J. A., & Pakkenberg, B. (2010). Application of stereological estimates in patients with severe head injuries using CT and MR scanning images.. The British Journal of Radiology, 83 (988), 307-17. doi:10.1259/bjr/18575224
  • Lu, X. M., Si, Y., Williams, A. J., Hartings, J. A., Gryder, D., & Tortella, F. C. (2009). NNZ-2566, a glypromate analog, attenuates brain ischemia-induced non-convulsive seizures in rats.. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 29 (12), 1924-32. doi:10.1038/jcbfm.2009.109
  • Hartings, J. A., Strong, A. J., Fabricius, M., Manning, A., Bhatia, R., Dreier, J. P., Mazzeo, A. T., Tortella, F. C., & Bullock, M. R. (2009). Spreading depolarizations and late secondary insults after traumatic brain injury.. Journal of Neurotrauma, 26 (11), 1857-66. doi:10.1089/neu.2009-0961
  • Hartings, J. A., Watanabe, T., Dreier, J. P., Major, S., Vendelbo, L., & Fabricius, M. (2009). Recovery of slow potentials in AC-coupled electrocorticography: application to spreading depolarizations in rat and human cerebral cortex.. Journal of Neurophysiology, 102 (4), 2563-75. doi:10.1152/jn.00345.2009
  • Dreier, J. P., Major, S., Manning, A., Woitzik, J., Drenckhahn, C., Steinbrink, J., Tolias, C., Oliveira-Ferreira, A. I., Fabricius, M., Hartings, J. A., Vajkoczy, P., Lauritzen, M., Dirnagl, U., Bohner, G., & Strong, A. J. (2009). Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage.. Brain : A Journal of Neurology, 132 (Pt 7), 1866-81. doi:10.1093/brain/awp102
  • Hartings, J. A., Gugliotta, M., Gilman, C., Strong, A. J., Tortella, F. C., & Bullock, M. R. (2008). Repetitive cortical spreading depolarizations in a case of severe brain trauma.. Neurological Research, 30 (8), 876-82. doi:10.1179/174313208X309739
  • Fabricius, M., Fuhr, S., Willumsen, L., Dreier, J. P., Bhatia, R., Boutelle, M. G., Hartings, J. A., Bullock, R., Strong, A. J., & Lauritzen, M. (2008). Association of seizures with cortical spreading depression and peri-infarct depolarisations in the acutely injured human brain.. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 119 (9), 1973-84. doi:10.1016/j.clinph.2008.05.025
  • Wei, G., Hartings, J. A., Yang, X., Tortella, F. C., & Lu, X. M. (2008). Extraluminal cooling of bilateral common carotid arteries as a method to achieve selective brain cooling for neuroprotection.. Journal of Neurotrauma, 25 (5), 549-59. doi:10.1089/neu.2007.0498
  • Williams, A. J., Tortella, F. C., Gryder, D., & Hartings, J. A. (2008). Topiramate reduces non-convulsive seizures after focal brain ischemia in the rat.. Neuroscience Letters, 430 (1), 7-12. doi:10.1016/j.neulet.2007.09.052
  • Strong, A. J., Hartings, J. A., & Dreier, J. P. (2007). Cortical spreading depression: an adverse but treatable factor in intensive care?. Current Opinion in Critical Care, 13 (2), 126-33. doi:10.1097/MCC.0b013e32807faffb
  • Dreier, J. P., Woitzik, J., Fabricius, M., Bhatia, R., Major, S., Drenckhahn, C., Lehmann, T., Sarrafzadeh, A., Willumsen, L., Hartings, J. A., Sakowitz, O. W., Seemann, J. H., Thieme, A., Lauritzen, M., & Strong, A. J. (2006). Delayed ischaemic neurological deficits after subarachnoid haemorrhage are associated with clusters of spreading depolarizations.. Brain : A Journal of Neurology, 129 (Pt 12), 3224-37. doi:10.1093/brain/awl297
  • Williams, A. J., Hartings, J. A., Lu, X. M., Rolli, M. L., & Tortella, F. C. (2006). Penetrating ballistic-like brain injury in the rat: differential time courses of hemorrhage, cell death, inflammation, and remote degeneration.. Journal of Neurotrauma, 23 (12), 1828-46. doi:10.1089/neu.2006.23.1828
  • Williams, A. J., Bautista, C. C., Chen, R., Dave, J. R., Lu, X. M., Tortella, F. C., & Hartings, J. A. (2006). Evaluation of gabapentin and ethosuximide for treatment of acute nonconvulsive seizures following ischemic brain injury in rats.. The Journal of Pharmacology and Experimental Therapeutics, 318 (3), 947-55. doi:10.1124/jpet.106.105999
  • Hartings, J. A., Tortella, F. C., & Rolli, M. L. (2006). AC electrocorticographic correlates of peri-infarct depolarizations during transient focal ischemia and reperfusion.. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 26 (5), 696-707. doi:10.1038/sj.jcbfm.9600223
  • Lu, X. M., Williams, A. J., Wagstaff, J. D., Tortella, F. C., & Hartings, J. A. (2005). Effects of delayed intrathecal infusion of an NMDA receptor antagonist on ischemic injury and peri-infarct depolarizations.. Brain Research, 1056 (2), 200-8. doi:10.1016/j.brainres.2005.07.041
  • Yao, C., Williams, A. J., Hartings, J. A., Lu, X. M., Tortella, F. C., & Dave, J. R. (2005). Down-regulation of the sodium channel Na(v)1.1 alpha-subunit following focal ischemic brain injury in rats: in situ hybridization and immunohistochemical analysis.. Life Sciences, 77 (10), 1116-29. doi:10.1016/j.lfs.2005.02.008
  • Williams, A. J., Hartings, J. A., Lu, X. M., Rolli, M. L., Dave, J. R., & Tortella, F. C. (2005). Characterization of a new rat model of penetrating ballistic brain injury.. Journal of Neurotrauma, 22 (2), 313-31. doi:10.1089/neu.2005.22.313
  • Khatri, V., Hartings, J. A., & Simons, D. J. (2004). Adaptation in thalamic barreloid and cortical barrel neurons to periodic whisker deflections varying in frequency and velocity.. Journal of Neurophysiology, 92 (6), 3244-54. doi:10.1152/jn.00257.2004
  • Williams, A. J., Tortella, F. C., Lu, X. M., Moreton, J. E., & Hartings, J. A. (2004). Antiepileptic drug treatment of nonconvulsive seizures induced by experimental focal brain ischemia.. The Journal of Pharmacology and Experimental Therapeutics, 311 (1), 220-7. doi:10.1124/jpet.104.069146
  • Lu, X. M., Williams, A. J., Yao, C., Berti, R., Hartings, J. A., Whipple, R., Vahey, M. T., Polavarapu, R. G., Woller, K. L., Tortella, F. C., & Dave, J. R. (2004). Microarray analysis of acute and delayed gene expression profile in rats after focal ischemic brain injury and reperfusion.. Journal of Neuroscience Research, 77 (6), 843-57. doi:10.1002/jnr.20218
  • Hartings, J. A., Rolli, M. L., Lu, X. M., & Tortella, F. C. (2003). Delayed secondary phase of peri-infarct depolarizations after focal cerebral ischemia: relation to infarct growth and neuroprotection.. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience, 23 (37), 11602-10.
  • Hartings, J. A., Temereanca, S., & Simons, D. J. (2003). Processing of periodic whisker deflections by neurons in the ventroposterior medial and thalamic reticular nuclei.. Journal of Neurophysiology, 90 (5), 3087-94. doi:10.1152/jn.00469.2003
  • Williams, A. J., Lu, X. M., Hartings, J. A., & Tortella, F. C. (2003). Neuroprotection assessment by topographic electroencephalographic analysis: effects of a sodium channel blocker to reduce polymorphic delta activity following ischaemic brain injury in rats.. Fundamental & Clinical Pharmacology, 17 (5), 581-93.
  • Hartings, J. A., Temereanca, S., & Simons, D. J. (2003). State-dependent processing of sensory stimuli by thalamic reticular neurons.. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience, 23 (12), 5264-71.
  • Hartings, J. A., Williams, A. J., & Tortella, F. C. (2003). Occurrence of nonconvulsive seizures, periodic epileptiform discharges, and intermittent rhythmic delta activity in rat focal ischemia.. Experimental Neurology, 179 (2), 139-49.
  • Pinto, D. J., Hartings, J. A., Brumberg, J. C., & Simons, D. J. (2003). Cortical damping: analysis of thalamocortical response transformations in rodent barrel cortex.. Cerebral Cortex (New York, N.Y. : 1991), 13 (1), 33-44.
  • Kelly, M. K., Carvell, G. E., Hartings, J. A., & Simons, D. J. (2001). Axonal conduction properties of antidromically identified neurons in rat barrel cortex.. Somatosensory & Motor Research, 18 (3), 202-10.
  • Hartings, J. A., & Simons, D. J. (2000). Inhibition suppresses transmission of tonic vibrissa-evoked activity in the rat ventrobasal thalamus.. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience, 20 (19), RC100.
  • Hartings, J. A., Temereanca, S., & Simons, D. J. (2000). High responsiveness and direction sensitivity of neurons in the rat thalamic reticular nucleus to vibrissa deflections.. Journal of Neurophysiology, 83 (5), 2791-801.
  • Hartings, J. A., & Simons, D. J. (1998). Thalamic relay of afferent responses to 1- to 12-Hz whisker stimulation in the rat.. Journal of Neurophysiology, 80 (2), 1016-9.
  • Fraser, G., Hartings, J. A., & Simons, D. J. Adaptation of trigeminal ganglion cells to periodic whisker deflections.. Somatosensory & Motor Research, 23 (3-4), 111-8. doi:10.1080/08990220600906589
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Book Chapter
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  • Revanker GS, Winkler MKL, Major S., Schoknecht K, Heinemann U, Woltzik J, Classen J, Hartings JA, Dreier JP(In Press). Spreading depolarizations and seizures in clinical subdural electrcorticographic records ,In Seizures in Critical Care.
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Invited Presentations
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  • Hartings, JA (11/01/2003). Coding, bursting, and filtering; the whisker-related thalamus.Barrels XVI ,Covington, LA. Professional Meeting. National
  • Hartings, JA (08/01/2004). Penetrating brain injury in the rat: electrocorticograpy and pathophysiology.Advanced Technologies in Combat Casualty Care ,St. Pete Beach, FL. Conference. National
  • Hartings, JA (03/01/2005). Silent Seizures in brain injury; electrophysiology and anti-seizure pharmacology.The Technical Corporation Program ,Brisbane, Australia. Conference. International
  • Hartings, JA (03/01/2005). Cortical spreading depression in brain injury from bench to bedside.The Technical Cooperation Program ,Brisbane, Australia. Conference. International
  • Hartings, JA (08/01/2005). Incidence of cortical spreading depression in the injured human brain.Advanced Technologies in Combat Casualty Care ,St. Pete Beach,m FL. Conference. University
  • Hartimgs, JA (07/23/2008). Cortical spreading depolarizations following acute injury to the human brain.Gordon Researcj Conference BioelectrochemistryConference.
  • Hartings, JA (06/01/2009). Spreading depolarizations and In-Hospital Secondaryinsults after Tramatic Brain Injury.Brain 09: International Society for Cerebral Blood Flow and Metabolism ,Chicago, IL. Conference. National
  • Hartings, JA (12/01/2009). Secondary brain damage from non-convulsive seizures and spreading depolarizations; evidence from animals and humans.American Epilepsy Society ,Boston, MA. Conference. National
  • Hartings, JA (02/01/2010). Neurophysiology of acute brain injury; seizures, periodic patterns, and cortical spreading depression.American Clinical Neurophysiology Society ,San Diego, CA. Conference. National
  • Hartings, JA (05/06/2010). What are slow potential changes? and Spreading depolarizations as an independent predictor of poor outcome in TBI.COSBID XII ,Barcelona, Spain. Conference. International
  • Hartings, JA (08/27/2010). Neurophysiology spreading depression.Tomographic Physiologic Imaging and Multimodal Monitoring ,Sante Fe, NM. Conference. National
  • Hartings, JA (01/24/2011). Spreading depolarizations: a paradigm shift in severe brain trauma?.Winter Conference on Brain Research ,Keystone, CO. Conference. National
  • Hartings, JA (07/13/2011). Neuromonitoring Techniques: ECoG.National Nuerotrauma Symposium ,Hollywood, FL. Conference. National
  • Hartings, JA (11/23/2011). Spreading depolarization and outcome after traumatic brain injury: a prospective observational study.International Razavi Neurotrauma Congress ,Mashhad, Iran. Conference. International
  • Hastings, JA (10/05/2012). What do cortical spreading depolorizations mean to neurocritical care patients?.Neurocritical Care Society Meeting ,Denver, CO. Conference. National
  • Hastings, JA (10/06/2012). Developing a research consortium in neurocritical care.Neurocritical Care Societh Meeting ,Denver, CO. Conference.
  • Hastings, JA (09/21/2012). A noval ventricular drinage catheter for mullimodel monitoring using BioMEMS sensore.COSBID XIV ,London, UK. Professional Meeting. International
  • Hastings, JA (01/25/2013). Research in international networks: transatlantic databanks.ANIM 2013, a joint meeting with DGNI & NCS ,Mannheim, Germany. Professional Meeting. International
  • Hastings, JA (09/13/2013). Update on spreading depolarizations in TBI Perspectives on a treatment trial for spreading depolarizations, and Electrocorticograophy with the Moberg Component Neuromonitotring System.COSBID XV ,Innsbruck, Austria. Professional Meeting. International
  • Hastings, JA (03/20/2014). Monitoring a neuronal pathophysiologic process in traumatic brain injury.International Neurotrauma Society Symposium ,Budapest, Hungary. Professional Meeting. International
  • Hastings, JA (07/08/2014). Spreading depolarizations in acute brain injury: mathematical dynamic instability of cerebral cortex?.Neurovascular Coupling and Related Phenomena ,Toronto, Canada. Professional Meeting. International
  • Hartings, JA (02/11/2015). Spreading depolarizations in clinical TBI: triggers, modulators, and causation.International Stroke Conference ,Nashville, TN. Professional Meeting. International
  • Hastings, JA (07/29/2015). Spreading depolarizaitons in clinical TBI: triggers, modulators, and causation.Brain 15: International Society for Cerebral Blood Flow and Metabolism ,Vancouver, Canada. Professional Meeting. International
  • Hastings, JA (04/01/2016). Cortical Spreading Depression New Formulations of Old Phenomena.American Academy of Neurology ,Vancouver, BC. Professional Meeting. International
  • Hartings, JA (06/27/2016). Real-time detection of lesion development in acute brain injury.National Neurotrauma Society Symposium ,Lexington, KY. Professional Meeting. National
  • Hartings, JA (06/29/2016). Cortical spreading depolarization real-time lesion monitoring in acute brain injury (Keynote).Internaitonal Symposium on Intracranial Pressure and Neuromonitoring
  • Hastings, JA (07/16/2016). Perspective on the COSBID consortium: mission, history, and future (KKeynote).COSBID XVII
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Poster Presentations
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  • Carroll CP, Krueger BM, Mahoney EJ, Hinzman JM, Hartings JA (10/07/2017). (In Progress). A porcine model of early cortical infarction after subarachnoid hemorrhage..Congress of Neurological Surgeons ,Boston, MA. Professional Meeting. National
  • Carroll CP, Krueger BM, Mahoney EJ, Hinzman JM, Hartings JA. (04/18/2017). Subarachnoid hemorrhage acutely induces cortical spreading depolarizations and early cortical infarction. -- Best Resident Abstract Award.UCGNI Research Day ,Cincinnati, OH. UC. University
  • Foreman B, Pahren L, Davari H, Hartings JA, Ngwenya L, Lee J. (03/02/2017). Leveraging predictive analytics to assess ICP-related neuronal dysfunction following severe traumatic brain injury.Neuroscience in Intensive Care International Symposium ,Washington, DC. Professional Meeting. National
  • Ngwenya L, Stoddard E, Andaluz N, Hartings J, Foreman B. (07/07/2017). Multimodality monitoring in severe traumatic brain injury: clinical feasibility and reliability. National Neurotrauma Symposium.National Neurotrauma Symposium ,Snowbird, Utah. Conference. National
  • Hartings JA, Major S, DiNapoli V, Winkler MKL, Hinzman JM, Foreman B, Woitzik J, Andaluz N, Carlson A, Dreier JP. (07/07/2017). Terminal depolarization follows electrical silence in death of the human cerebral cortex. .National Neurotrauma Symposium ,Snowbird, Utah. Conference. National
  • Dreier JP, Major S, Hartings JA. (04/01/2017). Nonspreading depression followed by spreading depolarization in patients with cardiac arrest and analysis of platinum-iridium electrode interferences with oxygen and pH. Brain2017 and International Conference on Spreading Depolarizations.Berlin BRAIN & BRAIN PET 2017, the 28rd International Symposium on Cerebral Blood Flow, Metabolism and Function and the 13th International Conference on Quantification of Brain Function with PET ,Berlin, Germany. Professional Meeting. International
  • Hinzman JM, Krueger B, Tackla R, Hartings JA (04/01/2016). Continuum of spreading depolarizations in rat model of acute subdural hematoma. . Ohio State Neurosurgical Society ,Cincinnati, OH. Professional Meeting. State
  • Hartings JA, Hinzman JM, Wilson A, Andaluz N, Lingsma H, Mathern B, Pahl C, Shutter LA, Vagal A, Bullock MR, Strong AJ, Okonkwo DO. (02/01/2016). Characterization of spreading depolarizations in severe traumatic brain injury: a prospective multi-center study.International Neurotrauma SocietyProfessional Meeting. International
  • York J, Hinzman JM, Mahoney EJ, Goodman MD, Hartings JA (08/17/2015). Spreading depolarizations in a swine model of traumatic brain injury.Military Health Science Research Symposium ,Ft. Lauderdale, FL. Other Institution.
  • Narayan RK, Li C, Wu P-M, Wu Z, Bhattacharjee N, Ahn C, Hartings JA (08/18/2015). A single device for simultaneous real-time monitoring of seven physiologic variables in the injured brain.Military Health Science Research Symposium ,Ft. Lauderdale, FL. Other Institution.
  • Tackla R, Hinzman JM, Foreman B, Magner M, Andaluz N, Hartings JA (03/10/2015). Assessment of cerebrovascular autoregulation using a regional cerebral blood flow monitor in severe brain trauma.Ohio State Neurosurgical Society ,Columbus, OH. Other Institution. University
  • York J, Hinzman JM, Mahoney E, Hartings JA (03/10/2015). Spreading depolarizations in a swine model of traumatic brain injury.Ohio State Neurosurgical Society ,Columbus, OH. Other Institution. University
  • Hinzman JA, DiNapoli VA, Gerhardt GA, Hartings JA (06/27/2015). Spreading depolarizations mediate excitotoxicity in development of acute cortical lesions. Brain.ISCBFM ,Van Couver, Canada. Professional Meeting. International
  • Hinzman JA, DiNapoli VA, Gerhardt GA, Hartings JA (04/10/2014). Spreading depolarizations mediate glutamate excitotoxicity in development of acute cortical lesions.National Neurotrauma Society ,San Francisco, CA. Professional Meeting. National
  • Hinzman JA, Andaluz N, Shutter LA, Okonkwo DO, Pahl C, Strong AJ, Dreier JP, Hartings JA (04/10/2014). Inverse neurovascular coupling to cortical spreading depolarizations in severe brain trauma.National Neurotrauma Society ,San Francisco, CA. Professional Meeting. National
  • Costello M, King C, Hinzman JM, Hartings JA (07/01/2013). Major ischemia transforms cortical spreading depolarizations into a pathophysiological process producing neuronal death. Best Poster Award.Medical Student Summer Research Program Symposium, Univ Cinti ,Cincinnati, OH. UC. University
  • Rahme R, Jimenez L, Ringer AJ, Abruzzo TA, Zuccarello M, Hartings JA. (09/08/2013). Intra-arterial verapamil inhibits cortical spreading depolarizations in patients with post-hemorrhagic cerebral vasospasm: preliminary evidence.XV WFNS World Congress of Neurosurgery ,Soeul, Korea Republic of. Professional Meeting. International
  • Li C, Wu Z, Hartings JA, Rajan N, Chahine N, Cheyuo C, Wang P, Wu P-M, Golanov EV, Ahn C, Narayan R (01/05/2012). Brain-Friendly Amperometric Enzyme Biosensor Based on Encapsulated Oxygen Generating Biomaterial.International IEEE EMBS Conference ,Hong Kong, China. Professional Meeting. International
  • Hocker S, Learney RM, Hartings J, Fabricius ME, Strong AJ (06/01/2012). Paradoxical elevation of serum glucose in TBI associated spreading depressions.Neurocritical Care 17(Suppl 2): S76 ,Chicago, IL. Professional Meeting. National
  • Hartings JA, Wilson JA, Pollandt S, Andaluz N, Ficker D, Shutter LA (09/01/2012). A matter of perspective: detection of spreading depolarizations by continuous EEG. Princeton Conference XXVIII.Princeton Conference XXVIII ,Cincinnati, OH. UC. University
  • Hartings JA, Wilson JA, Pollandt S, Andaluz N, Ficker D, Shutter LA (2012). A matter of perspective: detection of spreading depolarizations by continuous EEG.Journal of Neurotrauma 29(10): A-191
  • Li C, Wu Z, Hartings JA, Rajan N, Chahine N, Cheyuo C, Wang P, Wu P-M, Golanov EV, Ahn CH and Narayan RK (2012). Brain-friendly amperometric enzyme biosensor based on encapsulated oxygen generating biomaterial.IEEE EMBS
  • Li C, Wu P-M, Hartings JA, Narayan RK (2012). Cerebral blood flow sensor with in situ temperature and thermal conductivity compensation.IEEE MEMS
  • Dreier JP, Hartings JA. (2012). Spreading convulsions, spreading depolarization, and epileptogenesis in human cerebral cortex.Winter Conference on Brain Research ,Snowbird, Utah.
  • O’Phelan K, Sanchez-Chavez J, Nemeth Z, Morrison C, Jaggid J, Hartings J, Olvey S, Bullock MR. (2011). Evidence of metabolic stress associated with cortical spreading depression.Journal of Neurotrauma 28(6): A-93,
  • *Wilson JA, Shutter LA, Hartings JA (2011). A platform for multimodal data collection and research in neurocritical care. Neurocrit Care 16:S51.*Distinguished Poster Recognition
  • Li C, Wu P-M, Hartings JA, Narayan RK (2011). Smart catheter flow sensor for continuous regional cerebral blood flow monitoring.IEEE Sensors
  • *Wilson JA, Hartings JAA platform for multimodal data collection and research in neurocritical care.11th International Conference on Neurovascular Events after Subarachnoid Hemorrhage, *Young Investigator Award
  • Hertle D, Hartings JA, Woitzik J, Dreier JP, Vidgeon S, Strong AJ, Kowoll C, Dohmen C, Diedler J, Veltkamp R, Unterberg AW, Sakowitz OWAnalgesics and sedative drugs have an impact on frequency of spreading depolarizations in the injured human brain.11th International Conference on Neurovascular Events after Subarachnoid Hemorrhage
  • Zakrzewska A, Bullock R, Fabricius M, Maas A, Manning A, Murray G, Murray L, Okonkwo D, Pahl C, Shutter L, Vidgeon S, Woitzik J, Strong A, Hartings J (2011). Independent relationship of cortical spreading depolarizations with adverse outcome from traumatic brain injury. Joint EANS Annual Meeting.4th World ICH Conference
  • Li C, Hartings JA, Narayan RK (2011). Smart catheter intracortical electrodes for continuous monitoring of cerebral electrophysiology after traumatic brain injury.Annual Meeting of the Biomedical Engineering Society
  • Wash E, Serrone J, Hartings J, Andaluz N, Zuccarello M (2010). Venous thromboembolism in subarachnoid hemorrhage. American Association of Neurological Surgeons..
  • Bodo M, Pearce F, Garcia A, Van Albert S, Settle T, Szebeni J, Baranyi L, Hartings J, Armonda R (2010). In vivo cerebral blood flow autoregulation studies using rheoencephalography.Journal of Physics: Conference Series 224: 012088
  • Wilson JA, Shutter L, Hartings JA (2010). A system for real-time multimodal data integration and decision support during neurologic ICU monitoring.Tomographic Physiologic Imaging and Multimodal Monitoring
  • Hartings JA, Roozenbeek R, Fabricus M, Bullock MR, Okonkwo D, Mathern B, Bhatia R, Manning A, Vidgeon S, Woitzik J, Shutter L, Maas AIR, Strong AJ (2010). First evidence for an independent relationship of cortical depolarisations with adverse outcome in patients with traumatic brain injury.Society of British Neurological Surgeons Conference
  • *Wilson JA, Bullock MR, Hartings JA (2010). Association of spreading depolarizations with excitotoxicity and metabolic crisis in TBI: a clinical microdialysis study.Journal of Neurotrauma 27(5): A-4. *Top 10 Poster Award
  • Losiniecki AJ, Okonkwo DO, Shutter LA, Bullock MR, Strong AJ, Mathern B, Puccio A, Vidgeon S, Pahl C, Hartings JA (2010). Computed tomographic pathologies associated with cortical dysfunction after traumatic brain injury requiring surgery.Journal of Neurotrauma 27(5): A-87
  • Lu X-CM, Hartings JA, Cao Y, Tortella FC (2010). Characterization of periodic epileptiform discharges following penetrating ballistic-like brain injury in rats.Journal of Neurotrauma 27(5): A-34
  • Shutter L, Strong AJ, Fabricius M, Bullock MR, Okonkwo D, Sakowitz O, Woitzik J, Hartings JA (2009). Association of spreading depolarizations with poor outcome after traumatic brain injury: results from a pilot study.Neurocritical Care 11:S55
  • Pyne-Geithman G, Adeoye O, Hartings J, Bonomo J, Shutter L (2009). Quid pro quo: the role of “basic science” and its practitioners in neurocritical care research.Neurocritical Care 11:S206
  • Hartings JA, Strong AJ, Bullock R, Okonkwo D, Sakowitz O, Fabricius M (2009). Association of spreading depolarizations with poor outcome after severe traumatic brain injury: results from a pilot study.Journal of Neurotrauma 26:A42
  • Hartings JA, Strong AJ, Okonkwo D, Shutter L, Mathern B, Fabricius M, Dreier JP, Tortella FC, Bullock MR (2009). Spreading depolarizations as secondary insults after severe traumatic brain injury.Military Health Research Fo
  • Major S, Woitzik J, Drenckhahn C, Hartings JA, Fabricius M, Strong AJ, Dreier JP (2009). Normal’ and ‘inverse’ neurovascular coupling to cortical spreading depolarization in the human brain.Journal of Cerebral Blood Flow and Metabolism 29:S294
  • Hartings JA, Fabricius M, Dreier JP, Major S, Vendelbo L, Watanabe T (2008). Monitoring of spreading depolarizations in acute brain injury by full-band electrocorticography.Neurocritical Care 9:S30
  • Hartings JA, Manning A, Fabricius M, Bullock R, Strong A (2008). Cortical spreading depressions are associated with low arterial and cerebral perfusion pressures after traumatic brain injury in humans.Journal of Neurotrauma 25(7):883
  • Si Y, Lu M-X, Chao Y, Wei G, Yang X, Tortella FC, Hartings JA (2008). EEG changes following penetrating ballistic-like brain injury in rats – a power spectral analysis.Journal of Neurotrauma 25(7):906
  • Lu M-X, Si Y, Hartings JA, Tortella FC (2008). Characterization of early non-convulsive seizures following penetrating ballistic- like brain injury in rats using continuous EEG.Journal of Neurotrauma 25(7):898
  • Hartings JA, Fabricius M, Dreier JP, Major S, Vendelbo L, Watanabe T (2008). Recovery of slow potentials from AC-coupled electrocorticography: application to spreading depression and peri-infarct depolarizations in the human brain. Program No. 553.26. 2008 Neuroscience Meeting Planner.Washington, DC: Society for Neuroscience ,Online.
  • Fabricius M, Manning A, Hartings JA, Sakowitz O, Woitzek J, Willumsen L, Lauritzen M, Mitchell P, Strong AJ (2008). High incidence of cortical spreading depression in patients with intracerebral haematomas.Program No. 810.2. 2008 Neuroscience Meeting Planner ,Washington, DC: Society for Neuroscience, Online.
  • Dreier JP, Major S, Manning A, Woitzik J, Drenckhahn C, Steinbrink J, Tolias C, Fabricius M, Oliveira-Ferreira AI, Lauritzen M, Hartings J, Dirnagl U, Bohner G, Strong AJ (2008). ‘Normal’ and ‘inverse’ neurovascular coupling and suppression of low-frequency vascular fluctuations during cortical spreading depolarisation in the human brain.Program No. 810.1. 2008 Neuroscience Meeting Planner ,Washington, DC: Society for Neuroscience, 2008. Online.
  • Fioravanti B, Edelmayer R, Hartings JA, Tortella FC, French ED, Porreca F, Vanderah TW (2008). Behavioral changes in a rat model of cortical spreading depression.Program No. 849.9. 2008 Neuroscience Meeting Planner ,Washington, DC: Society for Neuroscience, 2008. Online..
  • Fabricius M, Fuhr S, Willumsen L, Strong AJ, Bhatia R, Boutelle M, Dreier JP, Hartings JA, Bullock R, Lauritzen M (2007). Cortical spreading depression and seizures co-occur after acute brain injur.American Epilepsy Society
  • Hartings JA, Fabricius M, Strong AJ, Bhatia R, Tortella FC, Bullock R (2007). Cortical spreading depolarizations are associated with high ICP and low MAP in severe TBI patients.National Neurotrauma Society
  • Hartings JA, Strong AJ, Bullock MR, Bhatia R, Fabricius M, Vo AH, Bell RS, Tortella FC, Ecklund JM, Armonda RA, Dreier JP (2006). Spreading depolarizations of cerebral cortex after brain injury: mechanism of injury progression and relevance to military neurotrauma.Army Science Conference
  • Fabricius M, Fuhr S, Willumsen L, Strong AJ, Bhatia R, Boutelle MG, Dreier JP, Hartings JA, Bullock MR, Lauritzen M (2006). Co-occurrence of cortical spreading depression and seizure activity in acutely injured human cerebral cortex.Society for Neuroscience
  • Gryder DS, Williams AJ, Guevarra PA, Pulcifur AM, Hartings JA, Tortella FC, Lu XM (2006). NNZ 2566 treatment reduces non-convulsive seizures in rat model of middle cerebral arterial occlusion (MCAo).Society for Neuroscience
  • Dreier JP, Woitzik J, Fabricius M, Bhatia R, Major S, Drenckhahn C, Lehmann T-N, Sarrafzadeh A, Willumsen L, Hartings JA, Sakowitz O, Lauritzen M, Strong AJ (2006). Clusters of prolonged spreading depolarizations are the electrocorticographic correlate of delayed ischemic infarcts after subarachnoid hemorrhage.Society for Neuroscience
  • Hartings JA, Bullock MR, Fabricius M, Bhatia R, Dreier JP, Tortella FC, Strong AJ (2006). Cortical spreading depression after traumatic and penetrating injury to the human brain.J. Neurotrauma 23(2): 761
  • Hartings JA, Mazzeo AT, Fabricius M, Tortella FC, Bullock MR (2005). Temperature effect on spreading depression incidence in the traumatically injured human brain.J. Neurotrauma 22(10): 1201
  • Hartings JA, Mazzeo AT, Fabricius M, Tortella FC, Bullock MRSpreading depolarizations in the injured human brain. Brain05; Meeting of International Soc. of Cereb. Blood Flow and Metab.
  • Whipple RA, Williams AJ, Dave JR, Tortella FC, Hartings JA (2004). Peri-infarct depolarizations regulate immediate early gene expression 8-24 hr following focal brain ischemia.Program No. 343.5, 2004 Abstract Viewer/Itinerary Planner ,Washington, DC: Society for Neuroscience.
  • Connors RA, Bauman RA, Long JB, Tortella FC, Hartings JA (2004). Incidence of cortical spreading depression in fluid percussion brain injury in the rat.Program No. 793.10, 2004 Abstract Viewer/Itinerary Planner ,Washington, DC: Society for Neuroscience.
  • Hartings JA, Williams AJ, Bautista CC, Tortella FC (2004). Penetrating brain injury in the rat: electroencephalography and persistence of spreading depression.Program No. 793.14, 2004 Abstract Viewer/Itinerary Planner ,Washington, DC: Society for Neuroscience.
  • Hartings JA, Williams AJ, Bauman RA, Long JB, Tortella FC (2004). Penetrating brain injury in the rat: IV. Persistence of cortical spreading depression.International Neurotrauma Society
  • Tortella FC, Williams AJ, Lu XM, Hartings JA (2994). Penetrating brain injury in the rat: V. Characterization of electroencephalographic abnormalities.International Neurotrauma Society
  • Williams AJ, Lu XM, Hartings JA, Rolli ML, Bautista C, Dave JR, Tortella FC (2004). Penetrating brain injury in the rat: I. Modeling a survivable, high velocity gunshot wound to the head without using a fired projectile.International Neurotrauma Society
  • Hartings JA, Rolli ML, Cunningham B, Stefanik C, Tortella FC (2003). Electroencephalographic signatures of spreading depression in non-anesthetized, brain-injured rats.Soc. Neurosci. Abstr. Vol 29
  • Williams AJ, Hartings JA, Cunningham B, Lu X-CM, Tortella FC (2003). Treatment of brain ischemia-induced non-convulsive seizures (NCS) in the rat with clinically available anti-epileptic drugs (AEDs).Soc. Neurosci. Abstr. Vol 29
  • Williams A, Lu X-CM, Hartings JA, Cunningham B, Stefanik C, Roland CL, Wagstaff JD, Tortella FC (2003). Intrathecal treatment of CGX-1007, conantokin-G, reduces infarction and prevents cortical spreading depression in a rat model of focal brain ischemia and reperfusion.Soc. Neurosci. Abstr. Vol 29
  • Yao C, Hartings JA, Lu X-C M, Williams AJ, Yu Z, Hale SL, Berti R, Tortella FC, Dave JR (2003). Down-regulation of sodium channel -subunit NAV1.1 mRNA and protein following ischemic brain injury.Soc. Neurosci. Abstr. Vol 29
  • Hartings JA, Rolli ML, Tortella FC (2003). Repetitive peri-infarct depolarizations at 8-18 h post-injury coincide with infarct growth in rat focal cerebral ischemia.J. Cereb. Blood Flow Metab. 23 Suppl (1): 294
  • Hartings JA, Rolli ML, Tortella FC (2003). Repetitive peri-infarct depolarizations at 8-18 h post-injury coincide with infarct growth in rat focal cerebral ischemia.J. Cereb. Blood Flow Metab. 23 Suppl (1): 294
  • Hartings JA, Tortella FC (2002). Continuous monitoring of spreading depression (SD) and ictal activity in the awake rat following focal cerebral ischemia.Program No. 695.5. 2002 Abstract Viewer/Itinerary Planner. ,Washington, DC: Society for Neuroscience, CD-ROM..
  • Kinjo M, Hartings JA, Lu X-CM, Moreton JE, Tortella FC (2002). Non-convulsive seizures in rat focal cerebral ischemia and treatment with anti-epileptic drugs (AED)..Program No. 695.4. 2002 Abstract Viewer/Itinerary Planner ,Washington, DC: Society for Neuroscience, CD-ROM.
  • Khatri V, Hartings JA, Simons DJ (2002). Responses of excitatory and inhibitory barrel neurons to periodic whisker deflections.Program No. 45.5. 2002 Abstract Viewer/Itinerary Planner ,Washington, DC: Society for Neuroscience, CD-ROM.
  • Hartings JA, Williams AJ, Tortella FC (2001). EEG Characterization of non-convulsive seizures following focal cerebral ischemia in the rat.Soc. Neurosci. Abstr. Vol. 27, Program No. 552.4
  • Ives J, Jonas W, Hartings JA, Olufade A, Williams A, Eagles D, Tortella F (2001). Neuroprotection in experimental rat brain injury with ultra high dilution glutamate but not potassium chloride.Soc. Neurosci. Abstr. Vol. 27, Program No. 209.11
  • Dave JR, Stoica B, Williams AJ, Hartings JA, Yao C, Berti R, Faden A, Tortella F (2001). Studies on neuronal apoptosis following middle cerebral artery occlusion (MCAo)-mediated brain injury in rats.Soc. Neurosci. Abstr. Vol. 27, Program No. 773.16
  • Hartings JA, Simons DJ (1999). Entrainment of somatosensory thalamocortical circuitry in the rat by periodic (1-40 Hz) whisker stimulation. Somatosens.Mot. Res. 16(2): 179
  • Hartings JA, Temereanca S, Simons DJ (1999). Thalamic reticular nucleus control of thalamocortical activity in sensory afferent processing.Soc. Neurosci. Abstr
  • Hartings JA, Pinto DJ, Brumberg JC, Simons DJ (1997). Cortical amplification vs. damping: mechanisms of response tuning in local circuits.Soc. Neurosci. Abstr
  • Hartings JA, Pinto DJ, Simons DJ (1999). Recurrent excitation and its control in a model of rat whisker/barrel cortex.Soc. Neurosci. Abstr. 2: 1359
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Human Protocols
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  • Principal Investigator
    Hartings Ngwenya SDII
    COM Emergency Medicine

    Staff: Shivers, MacKenzie (Other Research Coordinator); Bell, Erin (Other Research Coordinator); Patel, Smruti (Sub-investigator); Deeds, Shannon (Coordinator); Robinson, Michael (Sub-investigator); Carroll, Christopher (Sub-investigator); Mandybur, George (Sub-investigator); Adeoye, Opeolu (Sub-investigator); Staarmann, Brittany (Sub-investigator); Gayda, Steven (Other Research Coordinator); Stark, Sara (Other Research Coordinator); Terry, Lauren (Other Research Coordinator); Gozal, Yair (Sub-investigator); Kosty, Jennifer (Sub-investigator); Harrison, Kathleen (Other Research Coordinator); Ngwenya, Laura (Other Research Coordinator); Blaze, Kelsey (Other Research Coordinator); Ringer, Andrew (Sub-investigator); Foreman, Brandon (Sub-investigator); Lutz, Jacob (Other Research Coordinator); Zuccarello, Mario (Sub-investigator); Schmit, Pamela (Other Research Coordinator); Spuzillo, Anthony (Other Research Coordinator); Andaluz, Norberto (Sub-investigator); Vester, Hannah (Other Research Coordinator); Kramer, Samantha (Other Research Coordinator); Saleh, Mohamed (Sub-investigator); Gogela, Steven (Sub-investigator); Naciff-Campos, Amanda (Other Research Coordinator); Merchant, Nalia (Other Research Coordinator); Cooley, Raechel (Other Research Coordinator)
    Approval Date:03/22/2017
  • Co-Investigator
    Hartings Ngwenya SDII
    COM Emergency Medicine

    Staff: Shivers, MacKenzie (Other Research Coordinator); Bell, Erin (Other Research Coordinator); Patel, Smruti (Sub-investigator); Deeds, Shannon (Coordinator); Robinson, Michael (Sub-investigator); Carroll, Christopher (Sub-investigator); Mandybur, George (Sub-investigator); Adeoye, Opeolu (Sub-investigator); Staarmann, Brittany (Sub-investigator); Gayda, Steven (Other Research Coordinator); Stark, Sara (Other Research Coordinator); Terry, Lauren (Other Research Coordinator); Gozal, Yair (Sub-investigator); Kosty, Jennifer (Sub-investigator); Harrison, Kathleen (Other Research Coordinator); Ngwenya, Laura (Other Research Coordinator); Blaze, Kelsey (Other Research Coordinator); Ringer, Andrew (Sub-investigator); Foreman, Brandon (Sub-investigator); Lutz, Jacob (Other Research Coordinator); Zuccarello, Mario (Sub-investigator); Schmit, Pamela (Other Research Coordinator); Spuzillo, Anthony (Other Research Coordinator); Andaluz, Norberto (Sub-investigator); Vester, Hannah (Other Research Coordinator); Kramer, Samantha (Other Research Coordinator); Saleh, Mohamed (Sub-investigator); Gogela, Steven (Sub-investigator); Naciff-Campos, Amanda (Other Research Coordinator); Merchant, Nalia (Other Research Coordinator); Cooley, Raechel (Other Research Coordinator)
    Approval Date:03/22/2017
  • Co-Investigator
    INSPECT
    COM Neurosurgery Clinical Trial
    University of Cincinnati
    Staff: Zuccarello, Mario (Sub-investigator); Krueger, Bryan (Sub-investigator); Staarmann, Brittany (Sub-investigator); McMahon, Nancy (Coordinator); Plummer, Zachary (Sub-investigator); Lopez, Omar (Coordinator); Robinson, Michael (Sub-investigator); Saleh, Mohamed (Sub-investigator); Money, Patricia (Coordinator); Foreman, Brandon (Sub-investigator); Mejia Munne, Juan (Sub-investigator); Ringer, Andrew (Sub-investigator); Kosty, Jennifer (Sub-investigator); Gogela, Steven (Sub-investigator); Yang, George (Sub-investigator); Andaluz, Norberto (Other); Carroll, Christopher (Sub-investigator); Patel, Smruti (Sub-investigator); Ngwenya, Laura (Sub-investigator); Jeong, William (Sub-investigator); Gozal, Yair (Sub-investigator)
    Approval Date:08/09/2017
  • Principal Investigator
    INSPECT
    COM Neurosurgery Clinical Trial
    University of Cincinnati
    Staff: Zuccarello, Mario (Sub-investigator); Krueger, Bryan (Sub-investigator); Staarmann, Brittany (Sub-investigator); McMahon, Nancy (Coordinator); Plummer, Zachary (Sub-investigator); Lopez, Omar (Coordinator); Robinson, Michael (Sub-investigator); Saleh, Mohamed (Sub-investigator); Money, Patricia (Coordinator); Foreman, Brandon (Sub-investigator); Mejia Munne, Juan (Sub-investigator); Ringer, Andrew (Sub-investigator); Kosty, Jennifer (Sub-investigator); Gogela, Steven (Sub-investigator); Yang, George (Sub-investigator); Andaluz, Norberto (Other); Carroll, Christopher (Sub-investigator); Patel, Smruti (Sub-investigator); Ngwenya, Laura (Sub-investigator); Jeong, William (Sub-investigator); Gozal, Yair (Sub-investigator)
    Approval Date:08/09/2017
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Animal Protocols
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  • Principal Investigator
    Spreading depolarizations in acute brain injury12-04-24-01
    Approved     Exp. Date: 04/09/2018
  • Research Team Member
    Optimal Fluid Study12-05-16-01
    Approved     Exp. Date: 07/20/2018
  • Principal Investigator
    Spreading Depolariations in Traumatic Brain Injury14-12-15-01
    Approved     Exp. Date: 02/25/2018
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