Education

  • Undergraduate: University of Notre Dame, 1995
  • Doctoral Degree: University of Pittsburgh School of Medicine, 2000

Research/Clinical Interests

  • Areas of expertise - pathophysiology and treatment of traumatic brain injury and stroke, with emphasis on spreading depression, seizures, and neuromonitoring

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Positions and Work Experience
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  • 2008-to Present,Director of Clinical Monitoring,Mayfield Clinic,Cincinnati, Ohio
  • 2008-to Present,Research Assistant Professor, Department of Neurosurgery,University of Cincinnati College of Medicine,Cincinnati, Ohio
  • 2004-2008,Chief, Neurophysiology Laboratory, Division of Psychiatry and Neuroscienceoscience, 2004-2008,Walter Reed Army Institute of Research,Silver Spring, Maryland
  • 2006-2008,U.S. Army: Major,Medical Service Corps
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Research Grants
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  • W81XWH-08-2-001609/01/2008-08/30/2012. Department of the Army Medical Research and Materiel Command. Spreading Depressions as Secondary Insults after Traumatic Injury to the Human Brain, PI, Active.
  • IPA DOD11/01/2008-08/31/2012. Department of the Army Medical Research and Materiel Command. Intergovernmental Personnel Act Agreement for Jed Hartings, PI, Active.
  • W81XWH-10-1-0977 / W91ZSQ0128N61009/30/2010-10/29/2015. Department of the Army Medical Research Acquisition Activity. Novel Smart Catheter for Multimodal Monitoring of the Head-Injured Warrior, PI, Active.
  • Hartings 201202/08/2012-02/07/2013. Upsher-Smith Laboratories, Inc.. Consulting Agreement with Upsher-Smith Laboratories, Inc, PI, Active.
  • Agreement No. 602150-209/01/2013-08/31/2014. European Union Commission. Collaboratirve European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI), PI, Active.
  • HOPES05/01/2015-04/30/2018. Vivian L Smith Foundation for Neurological Research. HypOthermia for Patients requiring Evacuation of Subdural Hematoma (HOPES): a Multicenter, Randomized Clinical Trial, Collaborator, Active.
  • W81XWH-16-2-0020 / BA15007507/15/2016-07/14/2020. Department of the Army Medical Research Acquisition Activity. Development and Validation of Spreading Depolarization Monitoring for TBI Management, PI, Awarded.
  • 2016-17 R. J. Dempsey Cerebrovascular Research Award07/01/2016-06/30/2017. American Association of Neurological Surgeons. Non-Traumatic Sulcal Subarachnoid Hemorrhage in a Porcine Model: Induction of Cortical Spreading Depolarization and Early Cortical Ischemia, PI, Active.
  • W81XWH-16-C-016109/30/2016-12/29/2020. Department of the Army Medical Research Acquisition Activity. Hypothermia for Patients Requiring Evacuation of Subdural Hematoma: Effect on Spreading Depolarizations, PI, Awarded.
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Peer Reviewed Publications (in chronological order)
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  • Li, C., Wu, Z., Limnuson, K., Cheyuo, C., Wang, P., Ahn, C. H., Narayan, R. K., & Hartings, J. A. (2016). Development and application of a microfabricated multimodal neural catheter for neuroscience.. Biomedical Microdevices, 18 (1), 8. doi:10.1007/s10544-016-0034-6
  • Li, C., Narayan, R. K., Wu, P., Rajan, N., Wu, Z., Mehan, N., Golanov, E. V., Ahn, C. H., & Hartings, J. A. (2016). Evaluation of microelectrode materials for direct-current electrocorticography.. Journal of Neural Engineering, 13 (1), 016008. doi:10.1088/1741-2560/13/1/016008
  • Toth, P., Szarka, N., Farkas, E., Ezer, E., Czeiter, E., Amrein, K., Ungvari, Z., Hartings, J. A., Buki, A., & Koller, A. (2016). Traumatic brain injury-induced autoregulatory dysfunction and spreading depression-related neurovascular uncoupling: Pathomechanisms, perspectives, and therapeutic implications.. American Journal of Physiology. Heart and Circulatory Physiology, 311 (5), H1118-H1131. doi:10.1152/ajpheart.00267.2016
  • Li, C., Narayan, R. K., Wang, P., & Hartings, J. A. (2016). Regional temperature and quantitative cerebral blood flow responses to cortical spreading depolarization in the rat.. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. doi:10.1177/0271678X16667131
  • Hartings, J. A., Shuttleworth, C. W., Kirov, S. A., Ayata, C., Hinzman, J. M., Foreman, B., Andrew, R. D., Boutelle, M. G., Brennan, K. C., Carlson, A. P., Dahlem, M. A., Drenckhahn, C., Dohmen, C., Fabricius, M., Farkas, E., Feuerstein, D., Graf, R., Helbok, R., Lauritzen, M., Major, S., Oliveira-Ferreira, A. I., Richter, F., Rosenthal, E. S., Sakowitz, O. W., Sánchez-Porras, R., Santos, E., Schöll, M., Strong, A. J., Urbach, A., Westover, M. B., Winkler, M. K., Witte, O. W., Woitzik, J., & Dreier, J. P. (2016). The continuum of spreading depolarizations in acute cortical lesion development: Examining Leão's legacy.. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. doi:10.1177/0271678X16654495
  • Dreier, J. P., Fabricius, M., Ayata, C., Sakowitz, O. W., William Shuttleworth, C., Dohmen, C., Graf, R., Vajkoczy, P., Helbok, R., Suzuki, M., Schiefecker, A. J., Major, S., Winkler, M. K., Kang, E., Milakara, D., Oliveira-Ferreira, A. I., Reiffurth, C., Revankar, G. S., Sugimoto, K., Dengler, N. F., Hecht, N., Foreman, B., Feyen, B., Kondziella, D., Friberg, C. K., Piilgaard, H., Rosenthal, E. S., Westover, M. B., Maslarova, A., Santos, E., Hertle, D., Sánchez-Porras, R., Jewell, S. L., Balança, B., Platz, J., Hinzman, J. M., Lückl, J., Schoknecht, K., Schöll, M., Drenckhahn, C., Feuerstein, D., Eriksen, N., Horst, V., Bretz, J. S., Jahnke, P., Scheel, M., Bohner, G., Rostrup, E., Pakkenberg, B., Heinemann, U., Claassen, J., Carlson, A. P., Kowoll, C. M., Lublinsky, S., Chassidim, Y., Shelef, I., Friedman, A., Brinker, G., Reiner, M., Kirov, S. A., Andrew, R. D., Farkas, E., Güresir, E., Vatter, H., Chung, L. S., Brennan, K. C., Lieutaud, T., Marinesco, S., Maas, A. I., Sahuquillo, J., Dahlem, M. A., Richter, F., Herreras, O., Boutelle, M. G., Okonkwo, D. O., Bullock, M. R., Witte, O. W., Martus, P., van den Maagdenberg, A. M., Ferrari, M. D., Dijkhuizen, R. M., Shutter, L. A., Andaluz, N., Schulte, A. P., MacVicar, B., Watanabe, T., Woitzik, J., Lauritzen, M., Strong, A. J., & Hartings, J. A. (2016). Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group.. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. doi:10.1177/0271678X16654496
  • Hartings, J. A., Li, C., Hinzman, J. M., Shuttleworth, C. W., Ernst, G. L., Dreier, J. P., Wilson, J. A., Andaluz, N., Foreman, B., & Carlson, A. P. (2016). Direct current electrocorticography for clinical neuromonitoring of spreading depolarizations.. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. doi:10.1177/0271678X16653135
  • Drenckhahn, C., Windler, C., Major, S., Kang, E., Scheel, M., Vajkoczy, P., Hartings, J. A., Woitzik, J., & Dreier, J. P. (2016). Complications in Aneurysmal Subarachnoid Hemorrhage Patients With and Without Subdural Electrode Strip for Electrocorticography.. Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society, 33 (3), 250-9. doi:10.1097/WNP.0000000000000274
  • Bogdanov, V. B., Middleton, N. A., Theriot, J. J., Parker, P. D., Abdullah, O. M., Ju, Y. S., Hartings, J. A., & Brennan, K. C. (2016). Susceptibility of Primary Sensory Cortex to Spreading Depolarizations.. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience, 36 (17), 4733-43. doi:10.1523/JNEUROSCI.3694-15.2016
  • Winkler, M. K., Dengler, N., Hecht, N., Hartings, J. A., Kang, E. J., Major, S., Martus, P., Vajkoczy, P., Woitzik, J., & Dreier, J. P. (2016). Oxygen availability and spreading depolarizations provide complementary prognostic information in neuromonitoring of aneurysmal subarachnoid hemorrhage patients.. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. doi:10.1177/0271678X16641424
  • Maas, A. I. R., Menon, D. K., Steyerberg, E. W., Citerio, G., Lecky, F., Manley, G. T., Hill, S., Legrand, V., & Sorgner, A. (2015). Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI): a prospective longitudinal observational study.. Neurosurgery, 76 (1), 67-80. doi:10.1227/NEU.0000000000000575
  • Tackla, R., Hinzman, J. M., Foreman, B., Magner, M., Andaluz, N., & Hartings, J. A. (2015). Assessment of Cerebrovascular Autoregulation Using Regional Cerebral Blood Flow in Surgically Managed Brain Trauma Patients.. Neurocritical Care. doi:10.1007/s12028-015-0146-5
  • Hinzman, J. M., DiNapoli, V. A., Mahoney, E. J., Gerhardt, G. A., & Hartings, J. A. (2015). Spreading depolarizations mediate excitotoxicity in the development of acute cortical lesions.. Experimental Neurology, 267, 243-53. doi:10.1016/j.expneurol.2015.03.014
  • Hinzman, J. M., Gibson, J. L., Tackla, R. D., Costello, M. S., Burmeister, J. J., Quintero, J. E., Gerhardt, G. A., & Hartings, J. A. (2015). Real-time monitoring of extracellular adenosine using enzyme-linked microelectrode arrays.. Biosensors & Bioelectronics, 74, 512-517. doi:10.1016/j.bios.2015.06.074
  • Li, C., Wu, P., Wu, Z., Limnuson, K., Mehan, N., Mozayan, C., Golanov, E. V., Ahn, C. H., Hartings, J. A., & Narayan, R. K. (2015). Highly accurate thermal flow microsensor for continuous and quantitative measurement of cerebral blood flow.. Biomedical Microdevices, 17 (5), 9992. doi:10.1007/s10544-015-9992-3
  • Li, C., Limnuson, K., Wu, Z., Amin, A., Narayan, A., Golanov, E. V., Ahn, C. H., Hartings, J. A., & Narayan, R. K. (2015). Single probe for real-time simultaneous monitoring of neurochemistry and direct-current electrocorticography.. Biosensors & Bioelectronics, 77, 62-68. doi:10.1016/j.bios.2015.09.021
  • Hinzman, J., Wilson, J. A., Mazzeo, A. T., Bullock, R., & Hartings, J. A. (2015). Excitotoxicity and Metabolic Crisis Are Associated with Spreading Depolarizations in Severe Traumatic Brain Injury Patients.. Journal of Neurotrauma. doi:10.1089/neu.2015.4226
  • Jeffcote, T., Hinzman, J. M., Jewell, S. L., Learney, R. M., Pahl, C., Tolias, C., Walsh, D. C., Hocker, S., Zakrzewska, A., Fabricius, M. E., Strong, A. J., Hartings, J. A., & Boutelle, M. G. (2014). Detection of spreading depolarization with intraparenchymal electrodes in the injured human brain.. Neurocritical Care, 20 (1), 21-31. doi:10.1007/s12028-013-9938-7
  • Hartings, J. A., Wilson, J. A., Look, A. C., Vagal, A., Shutter, L. A., Dreier, J. P., Ringer, A., & Zuccarello, M. (2013). Full-band electrocorticography of spreading depolarizations in patients with aneurysmal subarachnoid hemorrhage.. Acta Neurochirurgica. Supplement, 115, 131-41. doi:10.1007/978-3-7091-1192-5_27
  • Dreier, J. P., Drenckhahn, C., Woitzik, J., Major, S., Offenhauser, N., Weber-Carstens, S., Wolf, S., Strong, A. J., Vajkoczy, P., & Hartings, J. A. (2013). Spreading Ischemia After Aneurysmal Subarachnoid Hemorrhage.. Acta Neurochirurgica. Supplement, 115, 125-129. doi:10.1007/978-3-7091-1192-5_26
  • Wilson, J. A., Shutter, L. A., & Hartings, J. A. (2013). COSBID-M3: A Platform for Multimodal Monitoring, Data Collection, and Research in Neurocritical Care.. Acta Neurochirurgica. Supplement, 115, 67-74. doi:10.1007/978-3-7091-1192-5_15
  • Hartings, J. A., Vidgeon, S., Strong, A. J., Zacko, C., Vagal, A., Andaluz, N., Ridder, T., Stanger, R., Fabricius, M., Mathern, B., Pahl, C., Tolias, C. M., & Bullock, M. R. (2013). Surgical management of traumatic brain injury: a comparative-effectiveness study of 2 centers.. Journal of Neurosurgery. doi:10.3171/2013.9.JNS13581
  • Serrone, J. C., Wash, E. M., Hartings, J. A., Andaluz, N., & Zuccarello, M. (2013). Venous Thromboembolism in Subarachnoid Hemorrhage.. World Neurosurgery. doi:10.1016/j.wneu.2013.01.012
  • Li, C., Wu, P., Hartings, J. A., Wu, Z., Cheyuo, C., Wang, P., Ledoux, D., Shutter, L. A., Ramaswamy, B. R., Ahn, C. H., & Narayan, R. K. (2012). Micromachined lab-on-a-tube sensors for simultaneous brain temperature and cerebral blood flow measurements.. Biomedical Microdevices. doi:10.1007/s10544-012-9646-7
  • Drenckhahn, C., Winkler, M. K. L., Major, S., Scheel, M., Kang, E., Pinczolits, A., Grozea, C., Hartings, J. A., Woitzik, J., & Dreier, J. P. (2012). Correlates of spreading depolarization in human scalp electroencephalography.. Brain : A Journal of Neurology, 135 (Pt 3), 853-68. doi:10.1093/brain/aws010
  • Li, C., Wu, P., Wu, Z., Ahn, C. H., LeDoux, D., Shutter, L. A., Hartings, J. A., & Narayan, R. K. (2012). Brain temperature measurement: A study of in vitro accuracy and stability of smart catheter temperature sensors.. Biomedical Microdevices, 14 (1), 109-18. doi:10.1007/s10544-011-9589-4
  • Dreier, J. P., Major, S., Pannek, H., Woitzik, J., Scheel, M., Wiesenthal, D., Martus, P., Winkler, M. K. L., Hartings, J. A., Fabricius, M., Speckmann, E., & Gorji, A. (2012). Spreading convulsions, spreading depolarization and epileptogenesis in human cerebral cortex.. Brain : A Journal of Neurology, 135 (Pt 1), 259-75. doi:10.1093/brain/awr303
  • Hertle, D. N., Dreier, J. P., Woitzik, J., Hartings, J. A., Bullock, R., Okonkwo, D. O., Shutter, L. A., Vidgeon, S., Strong, A. J., Kowoll, C., Dohmen, C., Diedler, J., Veltkamp, R., Bruckner, T., Unterberg, A. W., & Sakowitz, O. W. (2012). Effect of analgesics and sedatives on the occurrence of spreading depolarizations accompanying acute brain injury.. Brain : A Journal of Neurology, 135 (Pt 8), 2390-2398. doi:10.1093/brain/aws152
  • Li, C., Wu, Z., Hartings, J. A., Rajan, N., Chahine, N., Cheyuo, C., Wang, P., Wu, P., Golanov, E. V., Ahn, C. H., & Narayan, R. K. (2012). Brain-friendly amperometric enzyme biosensor based on encapsulated oxygen generating biomaterial.. Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 2012, 6003-6. doi:10.1109/EMBC.2012.6347362
  • Hartings, J. A., Bullock, M. R., Okonkwo, D. O., Murray, L. S., Murray, G. D., Fabricius, M., Maas, A. I., Woitzik, J., Sakowitz, O., Mathern, B., Roozenbeek, B., Lingsma, H., Dreier, J. P., Puccio, A. M., Shutter, L. A., Pahl, C., & Strong, A. J. (2011). Spreading depolarisations and outcome after traumatic brain injury: a prospective observational study.. Lancet Neurology, 10 (12), 1058-64. doi:10.1016/S1474-4422(11)70243-5
  • Fioravanti, B., Kasasbeh, A., Edelmayer, R., Skinner, D. P., Hartings, J. A., Burklund, R. D., De Felice, M., French, E. D., Dussor, G. O., Dodick, D. W., Porreca, F., & Vanderah, T. W. (2011). Evaluation of cutaneous allodynia following induction of cortical spreading depression in freely moving rats.. Cephalalgia : An International Journal of Headache, 31 (10), 1090-100. doi:10.1177/0333102411410609
  • Hartings, J. A., Watanabe, T., Bullock, M. R., Okonkwo, D. O., Fabricius, M., Woitzik, J., Dreier, J. P., Puccio, A., Shutter, L. A., Pahl, C., & Strong, A. J. (2011). Spreading depolarizations have prolonged direct current shifts and are associated with poor outcome in brain trauma.. Brain : A Journal of Neurology, 134 (Pt 5), 1529-40. doi:10.1093/brain/awr048
  • Lauritzen, M., Dreier, J. P., Fabricius, M., Hartings, J. A., Graf, R., & Strong, A. J. (2011). Clinical relevance of cortical spreading depression in neurological disorders: migraine, malignant stroke, subarachnoid and intracranial hemorrhage, and traumatic brain injury.. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 31 (1), 17-35. doi:10.1038/jcbfm.2010.191
  • Lu, X. M., Hartings, J. A., Si, Y., Balbir, A., Cao, Y., & Tortella, F. C. (2011). Electrocortical pathology in a rat model of penetrating ballistic-like brain injury.. Journal of Neurotrauma, 28 (1), 71-83. doi:10.1089/neu.2010.1471
  • Oliveira-Ferreira, A. I., Milakara, D., Alam, M., Jorks, D., Major, S., Hartings, J. A., Lückl, J., Martus, P., Graf, R., Dohmen, C., Bohner, G., Woitzik, J., & Dreier, J. P. (2010). Experimental and preliminary clinical evidence of an ischemic zone with prolonged negative DC shifts surrounded by a normally perfused tissue belt with persistent electrocorticographic depression.. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 30 (8), 1504-19. doi:10.1038/jcbfm.2010.40
  • Eriksen, N., Rostrup, E., Andersen, K., Lauritzen, M. J., Fabricius, M., Larsen, V. A., Dreier, J. P., Strong, A. J., Hartings, J. A., & Pakkenberg, B. (2010). Application of stereological estimates in patients with severe head injuries using CT and MR scanning images.. The British Journal of Radiology, 83 (988), 307-17. doi:10.1259/bjr/18575224
  • Lu, X. M., Si, Y., Williams, A. J., Hartings, J. A., Gryder, D., & Tortella, F. C. (2009). NNZ-2566, a glypromate analog, attenuates brain ischemia-induced non-convulsive seizures in rats.. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 29 (12), 1924-32. doi:10.1038/jcbfm.2009.109
  • Hartings, J. A., Strong, A. J., Fabricius, M., Manning, A., Bhatia, R., Dreier, J. P., Mazzeo, A. T., Tortella, F. C., & Bullock, M. R. (2009). Spreading depolarizations and late secondary insults after traumatic brain injury.. Journal of Neurotrauma, 26 (11), 1857-66. doi:10.1089/neu.2009-0961
  • Hartings, J. A., Watanabe, T., Dreier, J. P., Major, S., Vendelbo, L., & Fabricius, M. (2009). Recovery of slow potentials in AC-coupled electrocorticography: application to spreading depolarizations in rat and human cerebral cortex.. Journal of Neurophysiology, 102 (4), 2563-75. doi:10.1152/jn.00345.2009
  • Dreier, J. P., Major, S., Manning, A., Woitzik, J., Drenckhahn, C., Steinbrink, J., Tolias, C., Oliveira-Ferreira, A. I., Fabricius, M., Hartings, J. A., Vajkoczy, P., Lauritzen, M., Dirnagl, U., Bohner, G., & Strong, A. J. (2009). Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage.. Brain : A Journal of Neurology, 132 (Pt 7), 1866-81. doi:10.1093/brain/awp102
  • Hartings, J. A., Gugliotta, M., Gilman, C., Strong, A. J., Tortella, F. C., & Bullock, M. R. (2008). Repetitive cortical spreading depolarizations in a case of severe brain trauma.. Neurological Research, 30 (8), 876-82. doi:10.1179/174313208X309739
  • Fabricius, M., Fuhr, S., Willumsen, L., Dreier, J. P., Bhatia, R., Boutelle, M. G., Hartings, J. A., Bullock, R., Strong, A. J., & Lauritzen, M. (2008). Association of seizures with cortical spreading depression and peri-infarct depolarisations in the acutely injured human brain.. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 119 (9), 1973-84. doi:10.1016/j.clinph.2008.05.025
  • Wei, G., Hartings, J. A., Yang, X., Tortella, F. C., & Lu, X. M. (2008). Extraluminal cooling of bilateral common carotid arteries as a method to achieve selective brain cooling for neuroprotection.. Journal of Neurotrauma, 25 (5), 549-59. doi:10.1089/neu.2007.0498
  • Williams, A. J., Tortella, F. C., Gryder, D., & Hartings, J. A. (2008). Topiramate reduces non-convulsive seizures after focal brain ischemia in the rat.. Neuroscience Letters, 430 (1), 7-12. doi:10.1016/j.neulet.2007.09.052
  • Strong, A. J., Hartings, J. A., & Dreier, J. P. (2007). Cortical spreading depression: an adverse but treatable factor in intensive care?. Current Opinion in Critical Care, 13 (2), 126-33. doi:10.1097/MCC.0b013e32807faffb
  • Dreier, J. P., Woitzik, J., Fabricius, M., Bhatia, R., Major, S., Drenckhahn, C., Lehmann, T., Sarrafzadeh, A., Willumsen, L., Hartings, J. A., Sakowitz, O. W., Seemann, J. H., Thieme, A., Lauritzen, M., & Strong, A. J. (2006). Delayed ischaemic neurological deficits after subarachnoid haemorrhage are associated with clusters of spreading depolarizations.. Brain : A Journal of Neurology, 129 (Pt 12), 3224-37. doi:10.1093/brain/awl297
  • Williams, A. J., Hartings, J. A., Lu, X. M., Rolli, M. L., & Tortella, F. C. (2006). Penetrating ballistic-like brain injury in the rat: differential time courses of hemorrhage, cell death, inflammation, and remote degeneration.. Journal of Neurotrauma, 23 (12), 1828-46. doi:10.1089/neu.2006.23.1828
  • Williams, A. J., Bautista, C. C., Chen, R., Dave, J. R., Lu, X. M., Tortella, F. C., & Hartings, J. A. (2006). Evaluation of gabapentin and ethosuximide for treatment of acute nonconvulsive seizures following ischemic brain injury in rats.. The Journal of Pharmacology and Experimental Therapeutics, 318 (3), 947-55. doi:10.1124/jpet.106.105999
  • Hartings, J. A., Tortella, F. C., & Rolli, M. L. (2006). AC electrocorticographic correlates of peri-infarct depolarizations during transient focal ischemia and reperfusion.. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 26 (5), 696-707. doi:10.1038/sj.jcbfm.9600223
  • Lu, X. M., Williams, A. J., Wagstaff, J. D., Tortella, F. C., & Hartings, J. A. (2005). Effects of delayed intrathecal infusion of an NMDA receptor antagonist on ischemic injury and peri-infarct depolarizations.. Brain Research, 1056 (2), 200-8. doi:10.1016/j.brainres.2005.07.041
  • Yao, C., Williams, A. J., Hartings, J. A., Lu, X. M., Tortella, F. C., & Dave, J. R. (2005). Down-regulation of the sodium channel Na(v)1.1 alpha-subunit following focal ischemic brain injury in rats: in situ hybridization and immunohistochemical analysis.. Life Sciences, 77 (10), 1116-29. doi:10.1016/j.lfs.2005.02.008
  • Williams, A. J., Hartings, J. A., Lu, X. M., Rolli, M. L., Dave, J. R., & Tortella, F. C. (2005). Characterization of a new rat model of penetrating ballistic brain injury.. Journal of Neurotrauma, 22 (2), 313-31. doi:10.1089/neu.2005.22.313
  • Khatri, V., Hartings, J. A., & Simons, D. J. (2004). Adaptation in thalamic barreloid and cortical barrel neurons to periodic whisker deflections varying in frequency and velocity.. Journal of Neurophysiology, 92 (6), 3244-54. doi:10.1152/jn.00257.2004
  • Williams, A. J., Tortella, F. C., Lu, X. M., Moreton, J. E., & Hartings, J. A. (2004). Antiepileptic drug treatment of nonconvulsive seizures induced by experimental focal brain ischemia.. The Journal of Pharmacology and Experimental Therapeutics, 311 (1), 220-7. doi:10.1124/jpet.104.069146
  • Lu, X. M., Williams, A. J., Yao, C., Berti, R., Hartings, J. A., Whipple, R., Vahey, M. T., Polavarapu, R. G., Woller, K. L., Tortella, F. C., & Dave, J. R. (2004). Microarray analysis of acute and delayed gene expression profile in rats after focal ischemic brain injury and reperfusion.. Journal of Neuroscience Research, 77 (6), 843-57. doi:10.1002/jnr.20218
  • Hartings, J. A., Rolli, M. L., Lu, X. M., & Tortella, F. C. (2003). Delayed secondary phase of peri-infarct depolarizations after focal cerebral ischemia: relation to infarct growth and neuroprotection.. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience, 23 (37), 11602-10.
  • Hartings, J. A., Temereanca, S., & Simons, D. J. (2003). Processing of periodic whisker deflections by neurons in the ventroposterior medial and thalamic reticular nuclei.. Journal of Neurophysiology, 90 (5), 3087-94. doi:10.1152/jn.00469.2003
  • Williams, A. J., Lu, X. M., Hartings, J. A., & Tortella, F. C. (2003). Neuroprotection assessment by topographic electroencephalographic analysis: effects of a sodium channel blocker to reduce polymorphic delta activity following ischaemic brain injury in rats.. Fundamental & Clinical Pharmacology, 17 (5), 581-93.
  • Hartings, J. A., Temereanca, S., & Simons, D. J. (2003). State-dependent processing of sensory stimuli by thalamic reticular neurons.. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience, 23 (12), 5264-71.
  • Hartings, J. A., Williams, A. J., & Tortella, F. C. (2003). Occurrence of nonconvulsive seizures, periodic epileptiform discharges, and intermittent rhythmic delta activity in rat focal ischemia.. Experimental Neurology, 179 (2), 139-49.
  • Pinto, D. J., Hartings, J. A., Brumberg, J. C., & Simons, D. J. (2003). Cortical damping: analysis of thalamocortical response transformations in rodent barrel cortex.. Cerebral Cortex (New York, N.Y. : 1991), 13 (1), 33-44.
  • Kelly, M. K., Carvell, G. E., Hartings, J. A., & Simons, D. J. (2001). Axonal conduction properties of antidromically identified neurons in rat barrel cortex.. Somatosensory & Motor Research, 18 (3), 202-10.
  • Hartings, J. A., & Simons, D. J. (2000). Inhibition suppresses transmission of tonic vibrissa-evoked activity in the rat ventrobasal thalamus.. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience, 20 (19), RC100.
  • Hartings, J. A., Temereanca, S., & Simons, D. J. (2000). High responsiveness and direction sensitivity of neurons in the rat thalamic reticular nucleus to vibrissa deflections.. Journal of Neurophysiology, 83 (5), 2791-801.
  • Hartings, J. A., & Simons, D. J. (1998). Thalamic relay of afferent responses to 1- to 12-Hz whisker stimulation in the rat.. Journal of Neurophysiology, 80 (2), 1016-9.
  • Fraser, G., Hartings, J. A., & Simons, D. J. Adaptation of trigeminal ganglion cells to periodic whisker deflections.. Somatosensory & Motor Research, 23 (3-4), 111-8. doi:10.1080/08990220600906589
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Human Protocols
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  • Principal Investigator
    INSPECT
    COM Neurosurgery Clinical Trial
    University of Cincinnati
    Staff: Ostling, Lauren (Sub-investigator); Gozal, Yair (Sub-investigator); Reinert, Rebecca (Coordinator); Dinapoli, Vincent (Sub-investigator); Sanders, Christopher (Sub-investigator); Magner, Mark (Sub-investigator); Hinzman, Jason (Sub-investigator); Jansen, Ian (Coordinator); Andaluz, Norberto (Other); Harwell, Daniel (Sub-investigator); Carroll, Christopher (Sub-investigator); Gogela, Steven (Sub-investigator); Pothukuchi, Sireesha (Other); Tackla, Ryan (Sub-investigator); Vuong, Shawn (Sub-investigator); Bixenmann, Benjamin (Sub-investigator); Koenig, Carolyn (Coordinator); Myers, Katie (Sub-investigator); Kosty, Jennifer (Sub-investigator); York, Jonathan (Sub-investigator); Jeong, William (Sub-investigator); Krueger, Bryan (Sub-investigator); Wilson, Jonathan (Sub-investigator); King, Cyrus (Sub-investigator); Patel, Smruti (Sub-investigator); Money, Patricia (Coordinator)
    Approval Date:09/18/2013
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Animal Protocols
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  • Principal Investigator
    Spreading depolarizations in acute brain injury12-04-24-01
    Approved     Exp. Date: 04/09/2018
  • Research Team Member
    Optimal Fluid Study12-05-16-01
    Approved     Exp. Date: 07/20/2018
  • Principal Investigator
    Spreading Depolariations in Traumatic Brain Injury14-12-15-01
    Approved     Exp. Date: 02/25/2018
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